Cell-to-Cell Variability Analysis Dissects the Plasticity of Signaling of Common γ Chain Cytokines in T Cells

Cell-to-Cell Variability Analysis Dissects the Plasticity of Signaling of Common γ Chain Cytokines in T Cells

This Research Article presents flow cytometric and mathematical analyses of the effect of increasing the abundance of the α subunit of the interleukin-2 (IL-2) receptor (IL-2Rα) on the responsiveness of mouse T cells to cytokines of the γc family, which includes IL-2 and IL-7. The data suggest that the increased IL-2Rα abundance decreases the sensitivity of T cells to IL-7 by sequestering the γc subunit away from the IL-7R, rendering it nonfunctional. The image shows an artist's depiction, looking down onto the cell surface, of the differential abundance of functional IL-7Rs (dimers) and IL-2Rs (trimers), both of which contain the γcsubunit (red), as a consequence of increased IL-2Rα abundance. [Image: Chris Bickel/AAAS]

Published Date: 
March, 2013