Searching for Magic Bullets

single domain antibody (shark VNAR) vs conventional antibody (Fv)

Single domain antibodies have emerged as a new class of therapeutic molecules in antibody engineering. A single domain antibody (shark VNAR), in contrast to a conventional antibody (Fv), is capable of binding a buried functional site consisting of the enzyme’s substrate binding pocket.  For additional information, see Ho, Searching for magic bullets, Antibody Therapeutics. DOI:

Laboratory of Molecular Biology

Antibody Therapeutics, Volume 1, Issue 1, 20 June 2018, Pages 1–5,

Published Date: 
June, 2018