Information analysis of sequences that bind the replication initiator RepA

cover of Journal of Molecular Biology, September 1993

The tall letters represent the highly conserved bases in DNA binding sites of several prokaryotic repressors and activators. Conservation is strongest where major grooves of the double helical DNA (represented by crests of a cosine wave) face the protein. This shows that conservation analysis alone can be used to predict the face of DNA that contacts the proteins.

RNA Biology Laboratory

Papp.Schneider1993 P. P. Papp D. K. Chattoraj, and T. D. Schneider. J. Mol. Biol. 233:219-230, 1993.

Published Date: 
September, 1993