Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation

cover of Nucleic Acids Research December 2001

Dubbed "Tom's T" by Dhruba Chattoraj, the unusually conserved thymine at position +7 in bacteriophage P1 plasmid RepA DNA binding sites rises above repressor and acceptor sequence logos. The T appears to represent base flipping prior to helix opening in this DNA replication initation protein.

Lab/Branch/Program: 
RNA Biology Laboratory
Citation: 

Schneider.baseflip.2001 T. D. Schneider. Nucleic Acids Res. 29:4881-4891, 2001.

Published Date: 
December, 2001