Cell protein cross-linking by erbstatin and related compounds

Cover of Biochemical Pharmacology, August 9, 1996

The scheme depicts a possible mechanism of cross-linking by erbstatin and related analogues. A mechanism of action is proposed which involves initial oxidation to reactive quinone intermediates that subsequently cross-link protein nucleophiles via multiple 1,4-Michael-type additions. Similar alkylation of protein by protein-tyrosine kinase inhibitors, such as herbimycin A, has been invoked. 


Chemical Biology Laboratory

Caroline Stanwell, Bin Ye, Stuart H Yuspa and Terrence R Burke Jr. in Biochemical Pharmacology 199652 (3), 475-480.

Published Date: 
August, 1996