Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities

Cover of ChemBioChem, September 24, 2010

The inside cover picture shows the molecular structure of a DAG lactone derivative on top of the inner leaflet of a DMPC bilayer. The confocal microscopy image illustrates DAG-lactone-stimulated membrane localization of PKCδ-ECFP in living cells, while the space-filling model shows the surface of the C1B domain of PKCδ, the target of the lactone. 

 

Lab/Branch/Program: 
Chemical Biology Laboratory
Citation: 

For more information, see: Membrane-Surface Anchoring of Charged Diacylglycerol-Lactones Correlates with Biological Activities by Or Raifman, Sofiya Kolusheva, Said El Kazzouli, Dina M. Sigano, Noemi Kedei, Nancy E. Lewin, Ruben Lopez-Nicolas, Ana Ortiz-Espin, Juan C. Gomez-Fernandez, Peter M. Blumberg, Victor E. Marquez, Senena Corbalan-Garcia and Raz Jelinek in ChemBioChem 201011 (14), 2003-2009

Published Date: 
September, 2010