Effect of North Bicyclo[3.1.0]hexane 2'-Deoxypseudosugars on RNA Interference: A Novel Class of siRNA Modification

Cover of ChemBioChem, May 2, 2011

The inside cover picture shows how siRNAs modified with North bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars are able to activate the RNA interference machinery. The paper confirms that the North conformation is critical for RNAi activity. 

 

Lab/Branch/Program: 
Chemical Biology Laboratory
Citation: 

For further details, see Effect of North Bicyclo[3.1.0]hexane 2'-Deoxypseudosugars on RNA Interference: A Novel Class of siRNA Modification by Montserrat Terrazas, Sandra M. Ocampo, José Carlos Perales, Victor E. Marquez and Ramon Eritja in ChemBioChem 201112 (7), 1056 – 1065.

Published Date: 
May, 2011