Application of Ring-Closing Metathesis to Grb2 SH3 Domain-Binding Peptides

Cover of Biopolymers Peptide Science, July 5, 2011

In silico-generated hypothetical interactions of a ring-closing metathesis-macrocylized peptide bound to the amino terminal SH3 domain of the growth factor receptor bound protein 2 (Grb2). The complex was derived from the NMR solution structure of the bound parent peptide, Ac-V-P-P-P-V-P-P-R-R-R-amide (Protein Data Bank: 3GBQ). The protein surface is shown as electrostatic potential (blue = positive; red = negative).

 

Lab/Branch/Program: 
Chemical Biology Laboratory
Citation: 

Fa Liu, Alessio Giubellino, Philip C. Simister, Wenjian Qian, Michael C. Giano, Stephan M. Feller, Donald P. Bottaro and Terrence R. Burke Jr. in Peptide Science201196 (6), 780–788.

Published Date: 
July, 2011