Unraveling the metabolic regulation of lysine acetyltransferases (KATs). Montgomery et al. detail the application of a competitive chemoproteomic strategy to quantitatively characterize the interactions of acyl-CoA metabolites with cellular KAT enzymes. These studies reveal KATs are strongly inhibited by lipid-derived CoA analogs, an interaction that may have implications for the metabolic regulation of epigenetic signaling, and highlight the power of chemoproteomics to rapidly characterize metabolic-epigenetic interactions in complex biological contexts.
Cover design by Scientific Publications, Graphics & Media, Frederick National Laboratory for Cancer Research.
See: Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors by David C. Montgomery#, Alexander W. Sorum#, Laura Guasch, Marc C. Nicklaus and Jordan L. Meier in Chemistry & Biology, 2015, 22, 1030-1039.