Clinical Trial Studies Combination Effect on Small Cell Lung Cancer

Posted: Jul 27, 2016

Dr. Anish Thomas, Staff Clinician in the Thoracic and GI Oncology Branch is conducting a clinical trial for small cell lung cancer (SCLC).

Clinical Trial Studies Combination Effect on Small Cell Lung Cancer

Liz Ness Receives the 2016 Distinguished Alumni Award from the University of Maryland School of Nursing

Posted: Jul 25, 2016

Liz Ness, Nurse Consultant for Education in the Office of the Clinical Director and former president of the University of Maryland School of Nursing (UMSON) Alumni Association was presented with the Distinguished Alumni Award at the 2016 UMSON Alumni Reunion. A 1993 graduate, Liz was honored for her “dedication to excellence and exceptional professional achievements.”

Liz Ness Receives the 2016 Distinguished Alumni Award from the University of Maryland School of Nursing

Dr. Jing Huang Receives Tenure

Posted: Jul 25, 2016

Dr. Jing Huang, Laboratory of Cancer Biology and Genetics, has received NIH Tenure. Dr. Huang’s research explores repression and activation of gene expression by the p53 tumor suppressor protein and the role this regulation has on embryonic and mesenchymal stem cell biology. Using genome wide and epigenetic approaches both in vitro and in mouse models, Jing’s work is contributing to our understanding of p53-related therapy for stem cell diseases and cancer.

Dr. Jing Huang Receives Tenure

Dr. Christine Alewine Appointed as a Lasker Investigator

Posted: Jul 25, 2016

Dr. Christine Alewine, Laboratory of Molecular Biology, has been appointed as a Lasker Scholar Tenure-Track Investigator. Dr. Alewine’s research focuses on using novel therapies to target pancreatic cancer, with an interest in immunotoxin therapeutics and how these can be used to improve outcomes for patients.

Dr. Christine Alewine Appointed as a Lasker Investigator

Dr. Subramaniam discusses using new high-tech microscopes in cancer research

Posted: Jul 21, 2016

Dr. Subramaniam discusses the new multimillion-dollar cryo-electron microscope installed this year at the Advanced Technology Research Facility (ATRF) in Frederick with the Frederick News Post.

Dr. Subramaniam discusses using new high-tech microscopes in cancer research

CURE Magazine Honors CCR Nurse Cindy Delbrook As “An Extraordinary Healer”

Posted: Jul 14, 2016

The Pediatric Oncology Branch’s (POB) Cindy Delbrook was recently honored by CURE Magazine as “An Extraordinary Healer” nominee. Written by former Investigator, Daniel “Trey” Lee, the essay is speaks to Cindy’s incredible dedication and compassion as an advocate, caregiver and friend to countless children and families that have passed through her door.

CURE Magazine Honors CCR Nurse Cindy Delbrook As “An Extraordinary Healer”

Dr. Jung-Min Lee Appointed as Lasker Scholar Investigator

Posted: Jul 12, 2016

CCR is pleased to announce the appointment of Jung-Min Lee, M.D. as a Lasker Scholar Investigator in the Women’s Malignancies Branch. Dr. Lee’s research focuses on investigating the biology of breast and ovarian cancers, developing novel therapeutic strategies, and evaluating these therapeutic approaches in clinical trials.

Dr. Jung-Min Lee Appointed as Lasker Scholar Investigator

Clinical Trial Combines Enzalutamide With Immunotherapy for Advanced Prostate Cancer

Posted: Jul 11, 2016

Dr. Ravi Madan, Clinical Director of the Genitourinary Malignancies Branch, is conducting a clinical trial for men who have metastatic prostate cancer but have not yet been treated with chemotherapy, abiraterone or enzalutamide.

Clinical Trial Combines Enzalutamide With Immunotherapy for Advanced Prostate Cancer

New Clinical Trial Combines LMB-100 with Nab-Paclitaxel for Metastatic or Locally Advanced Pancreatic Cancer

Posted: Jul 8, 2016

Christine Alewine, Lasker Scholar, in the Laboratory of Molecular Biology is conducting a clinical study for patients with pancreatic cancer using a new immunotoxin drug, called LMB-100. It is a targeted immunotherapy that delivers a toxin to cancer cells that make a protein called mesothelin that is made by most pancreatic cancers.

New Clinical Trial Combines LMB-100 with Nab-Paclitaxel for Metastatic or Locally Advanced Pancreatic Cancer

CCR Researchers Find DNA-binding Triggers Tetramerization of Glucocorticoid Receptor in Live Cells

Posted: Jul 7, 2016

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor and one of the most targeted proteins in the pharmaceutical industry due to its powerful antiinflammatory actions. The search for side effects-free glucocorticoids relies exclusively on a model wherein the GR oligomerization state, whether a monomer or a dimer, dictates its transcriptional output. Here, Dr. Gordon Hager, Dr. Diego Presman, and colleagues use an experimental approach where the GR–DNA interaction is observed in real time with a technique that allows the quantification of the oligomeric state of proteins in living cells. Unexpectedly, they find that DNA binding triggers tetramerization of the GR, which would be the truly activated form of the receptor. Their findings reveal a previously unidentified step in the glucocorticoid activation pathway.

CCR Researchers Find DNA-binding Triggers Tetramerization of Glucocorticoid Receptor in Live Cells

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