MPNST state of the science: outlining a research agenda for the future


Clinicians and scientists from around the world attended the MPNST meeting.

In October 2016, clinicians and scientists from around the world gathered on the NIH campus to exchange ideas on the future of malignant peripheral nerve sheath tumor (MPNST) research. The meeting was cosponsored by the Center for Cancer Research, the Division of Cancer Epidemiology and Genetics and the Children’s Tumor Foundation. The group reviewed the advances in MPNST research since the last consensus meeting took place in 2001 and broke out into working groups focused on addressing challenges in clinical trials methodology, diagnosis/imaging/and primary management, genomics/biomarkers, preclinical models and pathology/histology of MPNST. Expert pathologists got together to review the pathology of early MPNSTs and discuss how these lesions can be recognized in time to surgically remove them before they advance. A keynote speech by Dr. Shasha Jumbe of the Gates Foundation and a panel discussion by experts in big data presented new ideas on how MPNST researchers could harness MPNST data to develop new insights in MPNST biology and advance clinical care. The group is now working on follow-up action items for MPNST research and preparing a manuscript of the recommendations of the group.

Summary Posted: 10/2016