Combination therapy for non-small cell lung cancer studied in new clinical trial

doctor shaking hand of male patient

Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is slow growing and can affect smokers and non-smokers alike. David S. Schrump, M.D., Surgical Chief of the Thoracic and Gastrointestinal Oncology Branch, is leading the NCI’s participation in a multicenter trial of nivolumab with or without tetrahydrouridine-decitabine (THU-Dec) in patients with NSCLC. Nivolumab is a cancer drug that blocks the action of certain proteins that stop the immune system from attacking tumor cells. THU-Dec is composed of decitabine, a cancer drug that attacks abnormal cells in the body, and tetrahydrouridine, which helps decitabine work better. The aim of this study is to see if THU-Dec can boost the immune system’s response to nivolumab and improve outcomes for patients with NSCLC. 

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Summary Posted: Mon, 01/01/2018