Clinical trial tests combination therapy for malignant mesothelioma

Mesothelioma Spheroid

Mesothelioma spheroid
Photo courtesy of NCI Visuals Online

Patients with malignant mesothelioma may be eligible to participate in a new clinical trial at the NIH Clinical Center.

Raffit Hassan, M.D., of the Thoracic and GI Malignancies Branch is leading a study of a combination treatment for malignant mesothelioma. This type of cancer develops in the thin layer of tissue lining the chest or abdomen, often following exposure to airborne asbestos particles. In this study, patients will first receive an immunotoxin called LMB-100. This is a targeted immunotherapy that delivers a substance toxic to cancer cells that make a protein called mesothelin. Mesothelioma cells have an abnormally high amount of mesothelin on their surfaces. The second drug in the combination treatment is pembrolizumab. This immunotherapy agent blocks a protein pathway that allows cancer cells to hide from the immune system. By doing so, pembrolizumab helps the immune system to detect and attack cancer cells. Investigators want to see how well patients with mesothelioma respond to this combination treatment. 

Clinicaltrials.gov identifier: NCT03644550
NCI Protocol ID: NCI-18-C-0136
Official Title: Phase II Study of the Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma

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Summary Posted: 11/2018