Our Clinical Trials

Clinical studies taking place at the NIH Clinical Center led by MMP investigators are presented below. To search for additional myeloid malignancies clinical trials, please visit

Current Trials

Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS (Open - Recruiting)
Investigator: Kathy McGraw, Ph.D.
Contact: Christine McGowan    (240) 474-3584  

A Phase I/II Trial of BMS-986253 in Myelodysplastic Syndromes (Open - Recruiting)
ID: NCT05148234
Investigator:  Steven Pavletic, M.D.
Contact:  Christine McGowan    (240) 474-3584  

Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies (Open - Recruiting)
ID: NCT05588154
Investigator:  Kathy McGraw, Ph.D.
Contact:  Christine McGowan    (240) 474-3584 

Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus Host Disease (Open - Recruiting)
ID: NCT04294641
Investigator: Steven Z. Pavletic, M.D.
Contact: Steven Z. Pavletic, M.D.    (240) 760-6174

Natural History of Acquired and Inherited Bone Marrow Failure Syndromes (Open - Recruiting)
ID: NCT05012111
Investigator: Emma M. Groarke, M.D.
Contact: Katherine C. Roskom, R.N.    (301) 451-7094

Optimizing PTCy Dose and Timing (Open - Recruiting)
ID: NCT03983850
Investigator: Christopher G. Kanakry, M.D.
Contact: Amy H. Chai    (240) 858-3755

Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies (Open - Recruiting)
ID: NCT04959175
Investigator: Christopher G. Kanakry, M.D.
Contact: Jennifer L. Sadler    (240) 760-6172

CHIP/CCUS Natural History Protocol (Open - Recruiting)
ID: NCT04102423
InvestigatorEmma M. Groarke, M.D.
Contact:  Ivana Darden, R.N.    (301) 827-2988          

Longitudinal Studies of Patient With FPDMM (Open - Recruiting)
ID: NCT03854318
Investigator: Paul Liu, M.D.
Contact:  Natalie T. Deuitch    (301) 385-5205

A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome (Open - Not Yet Recruiting)
ID: NCT05027945
InvestigatorDennis Hickstein, M.D.
Contact: Dennis D Hickstein, M.D.    (240) 760-6169

Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations (Open - Recruiting)
ID: NCT01861106
Investigator: Dennis Hickstein, M.D.
Contact: Dennis D Hickstein, M.D.    (240) 760-6169

Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia (Open - Recruiting)
Investigator: Nirali Shah, M.D.
ID: NCT03971799
Contact: Hati Kobusingye    (763) 406-4385     
Contact: Erin Leckrone   (763) 406-5124    

Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation (Open - Recruiting)
Investigator:  Steven Pavletic, M.D.
ID: NCT02356159
Contact:  Ashley E Carpenter    (240) 858-3190 
Contact:  Steven Z Pavletic, M.D.    (240) 760-6174 

Phase I/II Trial of PLX3397 in Children and Young Adults with Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) (Open - Recruiting)
ID: NCT02390752
Investigator:  Rosandra Kaplan, M.D.
Contact:  Elaine W. Thomas    (240) 858-7013 
Contact:  Rosandra N Kaplan, M.D.    (240) 760-6198 

Cancer in Inherited Bone Marrow Failure Syndromes (Open - Recruiting)
ID: NCT00027274
Investigator:  Neelam Giri, M.D.
Contact:  Stephanie M Steinbart, R.N.    (800) 518-8474     
Contact:  Neelam Giri, M.D.    (240) 276-7256 

Natural History Study of GATA2 Deficiency and Related Disorders (Open - Recruiting)
Investigator:  Steven M Holland, M.D.
Contact: Merertu Tesso    (301) 402-7831
Contact: Steven M Holland, M.D.    (301) 402-7684

To search additional myeloid malignancies clinical trials, please visit