Maureen P. Martin, M.D.
Maureen P. Martin, M.D.
Staff Scientist (Contr)

Center for Cancer Research
National Cancer Institute

Bldg. 560, Rm 21-76
Frederick, MD 21702-1201
301-846-5318

Dr. Martin's research interests involve studies of host genetic effects on complex human diseases including infectious diseases, autoimmune diseases and cancer. Her focus is on genes known to participate in innate and acquired immunity, primarily the killer immunoglobulin-like receptor (KIR) genes and related loci.

Areas of Expertise
1) killer immunoglobulin-like receptor (KIR), 2) human leukocyte antigens (HLA)

Research Projects:

1. Determine the genetic effects of HLA and KIR variants on disease. Given the importance of KIR-mediated regulation of natural killer (NK) cell activity, their specificity for HLA class I allotypes, and their extensive genomic diversity, our efforts are geared towards characterizing the effects of KIR gene variation in resistance and susceptibility to diseases.

2. Characterize the molecular genetic properties of the KIR gene cluster. A greater understanding of the evolutionary and molecular genetic characteristics of the KIR gene cluster is also a main objective. This is especially important for genetic loci that consist of multiple homologues that share functional activity such as the KIR genes because it provides a significant aid in identifying the actual disease locus amongst multiple possibilities. Thus, we aim to determine levels of LD between KIR genes and alleles using segregation analysis in families and population based studies, and characterize the organization and frequency of recombinant KIR haplotypes.

Selected Publications
  1. Salie M, van der Merwe L, Möller M, Daya M, van der Spuy GD, van Helden PD, Martin MP, Gao XJ, Warren RM, Carrington M, Hoal EG.
    J Infect Dis. 209: 216-23, 2014. [ Journal Article ]
  2. Martin MP, Carrington M.
    Immunol Rev. 254: 245-64, 2013. [ Journal Article ]
  3. Pyo CW, Wang R, Vu Q, Cereb N, Yang SY, Duh FM, Wolinsky S, Martin MP, Carrington M, Geraghty DE.
    BMC Genomics. 14: 89, 2013. [ Journal Article ]
  4. Augusto DG, Zehnder-Alves L, Pincerati MR, Martin MP, Carrington M, Petzl-Erler ML.
    Immunogenetics. 64: 143-52, 2012. [ Journal Article ]
  5. Tomescu C, Duh FM, Hoh R, Viviani A, Harvill K, Martin MP, Carrington M, Deeks SG, Montaner LJ.
    AIDS. 26: 1869-78, 2012. [ Journal Article ]

Dr. Martin obtained her M.D. at the University of the West Indies, Jamaica in 1982 and completed a residency in pathology in 1989. She was a visiting research fellow in the Laboratory of Viral Carcinogenesis, NCI at Frederick from 1990-1995. Dr. Martin is currently a senior scientist (Leidos Biomedical Research, Inc.) in the HLA Immunogenetics Section of Dr. Mary Carrington, Laboratory of Experimental Immunology, Cancer and Inflammation Program. Her research interests involve studies of host genetic effects on complex human diseases including infectious diseases, autoimmune diseases and cancer. Her focus is on genes known to participate in innate and acquired immunity, primarily the killer Immunoglobulin-like receptor (KIR) genes and related loci.

Summary

Dr. Martin's research interests involve studies of host genetic effects on complex human diseases including infectious diseases, autoimmune diseases and cancer. Her focus is on genes known to participate in innate and acquired immunity, primarily the killer immunoglobulin-like receptor (KIR) genes and related loci.

Areas of Expertise
1) killer immunoglobulin-like receptor (KIR), 2) human leukocyte antigens (HLA)

Research

Research Projects:

1. Determine the genetic effects of HLA and KIR variants on disease. Given the importance of KIR-mediated regulation of natural killer (NK) cell activity, their specificity for HLA class I allotypes, and their extensive genomic diversity, our efforts are geared towards characterizing the effects of KIR gene variation in resistance and susceptibility to diseases.

2. Characterize the molecular genetic properties of the KIR gene cluster. A greater understanding of the evolutionary and molecular genetic characteristics of the KIR gene cluster is also a main objective. This is especially important for genetic loci that consist of multiple homologues that share functional activity such as the KIR genes because it provides a significant aid in identifying the actual disease locus amongst multiple possibilities. Thus, we aim to determine levels of LD between KIR genes and alleles using segregation analysis in families and population based studies, and characterize the organization and frequency of recombinant KIR haplotypes.

Publications

Selected Publications
  1. Salie M, van der Merwe L, Möller M, Daya M, van der Spuy GD, van Helden PD, Martin MP, Gao XJ, Warren RM, Carrington M, Hoal EG.
    J Infect Dis. 209: 216-23, 2014. [ Journal Article ]
  2. Martin MP, Carrington M.
    Immunol Rev. 254: 245-64, 2013. [ Journal Article ]
  3. Pyo CW, Wang R, Vu Q, Cereb N, Yang SY, Duh FM, Wolinsky S, Martin MP, Carrington M, Geraghty DE.
    BMC Genomics. 14: 89, 2013. [ Journal Article ]
  4. Augusto DG, Zehnder-Alves L, Pincerati MR, Martin MP, Carrington M, Petzl-Erler ML.
    Immunogenetics. 64: 143-52, 2012. [ Journal Article ]
  5. Tomescu C, Duh FM, Hoh R, Viviani A, Harvill K, Martin MP, Carrington M, Deeks SG, Montaner LJ.
    AIDS. 26: 1869-78, 2012. [ Journal Article ]

Biography

Dr. Martin obtained her M.D. at the University of the West Indies, Jamaica in 1982 and completed a residency in pathology in 1989. She was a visiting research fellow in the Laboratory of Viral Carcinogenesis, NCI at Frederick from 1990-1995. Dr. Martin is currently a senior scientist (Leidos Biomedical Research, Inc.) in the HLA Immunogenetics Section of Dr. Mary Carrington, Laboratory of Experimental Immunology, Cancer and Inflammation Program. Her research interests involve studies of host genetic effects on complex human diseases including infectious diseases, autoimmune diseases and cancer. Her focus is on genes known to participate in innate and acquired immunity, primarily the killer Immunoglobulin-like receptor (KIR) genes and related loci.