Luca  Gattinoni, M.D.
Luca Gattinoni, M.D.
Investigator

Center for Cancer Research
National Cancer Institute

Building 10 - CRC, Room 3E-3150
Bethesda, MD 20892
301-451-6914

Dr. Gattinoni is an Earl Stadtman investigator at the Experimental Transplantation and Immunology Branch, NCI. He is interested in uncovering the cellular and molecular mechanisms regulating T cell differentiation and the formation and maintenance of immunological memory. Specifically, his laboratory is focused on understanding the transcriptional, metabolic, and microRNA-mediated regulation of T cell self-renewal and multipotency with the goal of developing new T cell-based immunotherapies for the treatment of patients with advanced cancer and hematologic malignancies.

Areas of Expertise
1) Tumor immunology 2) Adoptive T cell therapy 3) Memory T cells 4) Transcriptional factors 5) microRNA 6) Immune metabolism
Selected Publications
  1. Ji Y, Wrzesinski C, Yu Z, Hu J, Gautam S, Hawk NV, Telford WG, Palmer DC, Franco Z, Sukumar M, Roychoudhuri R, Clever D, Klebanoff CA, Surh CD, Waldmann TA, Restifo NP, Gattinoni L
    Proc Natl Acad Sci U S A. 112: 476-481, 2015. [ Journal Article ]
  2. Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, Roychoudhuri R, Palmer DC, Muranski P, Karoly ED, Mohney RP, Klebanoff CA, Lal A, Finkel T, Restifo NP, Gattinoni L.
    J Clin Invest. 123: 4479-4488, 2013. [ Journal Article ]
  3. Ji Y, Pos Z, Rao M, Klebanoff CA, Yu Z, Sukumar M, Reger RN, Palmer DC, Borman ZA, Muranski P, Wang E, Schrump DS, Marincola FM, Restifo NP, Gattinoni L.
    Nat Immunol. 12: 1230-7, 2011. [ Journal Article ]
  4. Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP.
    Nat Med. 17: 1290-7, 2011. [ Journal Article ]
  5. Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP.
    Nat Med. 15: 808-13, 2009. [ Journal Article ]

Dr. Gattinoni received his M.D. from the Universita' degli Studi of Milan, Italy. Following the completion of his residency in medical oncology at the Istituto Nazionale Tumori in Milan, he joined the NCI in 2003 as a Visiting Fellow and became a Staff Scientist in 2008. In 2013, Dr. Gattinoni was appointed as an Earl Stadtman Tenure-Track Investigator at the Experimental Transplantation and Immunology Branch.

Name Position
Sanjivan Gautam Ph.D. Postdoctoral Fellow (Visiting)
Jinhui Hu Postdoctoral Fellow (Visiting)
Yun Ji Ph.D. Research Fellow

Summary

Dr. Gattinoni is an Earl Stadtman investigator at the Experimental Transplantation and Immunology Branch, NCI. He is interested in uncovering the cellular and molecular mechanisms regulating T cell differentiation and the formation and maintenance of immunological memory. Specifically, his laboratory is focused on understanding the transcriptional, metabolic, and microRNA-mediated regulation of T cell self-renewal and multipotency with the goal of developing new T cell-based immunotherapies for the treatment of patients with advanced cancer and hematologic malignancies.

Areas of Expertise
1) Tumor immunology 2) Adoptive T cell therapy 3) Memory T cells 4) Transcriptional factors 5) microRNA 6) Immune metabolism

Publications

Selected Publications
  1. Ji Y, Wrzesinski C, Yu Z, Hu J, Gautam S, Hawk NV, Telford WG, Palmer DC, Franco Z, Sukumar M, Roychoudhuri R, Clever D, Klebanoff CA, Surh CD, Waldmann TA, Restifo NP, Gattinoni L
    Proc Natl Acad Sci U S A. 112: 476-481, 2015. [ Journal Article ]
  2. Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, Roychoudhuri R, Palmer DC, Muranski P, Karoly ED, Mohney RP, Klebanoff CA, Lal A, Finkel T, Restifo NP, Gattinoni L.
    J Clin Invest. 123: 4479-4488, 2013. [ Journal Article ]
  3. Ji Y, Pos Z, Rao M, Klebanoff CA, Yu Z, Sukumar M, Reger RN, Palmer DC, Borman ZA, Muranski P, Wang E, Schrump DS, Marincola FM, Restifo NP, Gattinoni L.
    Nat Immunol. 12: 1230-7, 2011. [ Journal Article ]
  4. Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP.
    Nat Med. 17: 1290-7, 2011. [ Journal Article ]
  5. Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP.
    Nat Med. 15: 808-13, 2009. [ Journal Article ]

Biography

Dr. Gattinoni received his M.D. from the Universita' degli Studi of Milan, Italy. Following the completion of his residency in medical oncology at the Istituto Nazionale Tumori in Milan, he joined the NCI in 2003 as a Visiting Fellow and became a Staff Scientist in 2008. In 2013, Dr. Gattinoni was appointed as an Earl Stadtman Tenure-Track Investigator at the Experimental Transplantation and Immunology Branch.

Team

Name Position
Sanjivan Gautam Ph.D. Postdoctoral Fellow (Visiting)
Jinhui Hu Postdoctoral Fellow (Visiting)
Yun Ji Ph.D. Research Fellow