Antoun Toubaji, M.D.
Dr. Toubaji is a genitourinary (GU) pathologist. He is interested in studying GU solid tumors, particularly prostate cancer. His research focuses on prostate cancer significant molecular alterations, diagnostic and prognostic biomarkers, and validation of artificial intelligence (AI) and deep learning algorithms for detection and grading of prostate cancer.
1) prostate cancer, 2) molecular genetics and biomarkers, 3) genitourinary malignancies
I am an academic genitourinary (GU) pathologist and I am passionate about studying the histological features of GU malignancies. However, I am very interested in studying the genetic alteration of these tumors, as I believe it is the path for the future in diagnostic pathology. As prostate cancer remains a major health problem in the world, discovery and addition of new biomarkers and genetic alterations enhances the accuracy of prostate cancer clinicopathologic parameters (PSA, Gleason grade, stage) for the decision-making process toward optimal patient clinical management. Furthermore, application of artificial intelligence (AI) and deep learning systems enhances our accuracy and consistency in detecting, targeting and evaluating prostate cancer.
Selected Key Publications
Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas.Mod Pathol. 24(11): 1511-20, 2011. [ Journal Article ]
- Nat Genet. 42(8): 668-75, 2010. [ Journal Article ]
Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cancer: recognition of the syndrome by pathologic features and the utility of detecting aberrant succination by immunohistochemistry.Am J Surg Pathol. 38(5): 627-37, 2014. [ Journal Article ]
Immunohistochemical expression of minichromosome maintenance complex protein 2 predicts biochemical recurrence in prostate cancer: a tissue microarray and digital imaging analysis-based study of 428 cases.Hum Pathol. 43(11): 1852-65, 2012. [ Journal Article ]
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer.Nat Commun. 10(1): 4332, 2019. [ Journal Article ]
Dr. Toubaji received his medical degree from Damascus University Faculty of Medicine and has completed cancer research fellowships at the National Cancer Institute and at the Johns Hopkins Medical Institutions/Department of Pathology. He has completed a pathology residency training (AP/CP) at Georgetown University, an oncologic surgical pathology fellowship and a genitourinary pathology fellowship at Memorial Sloan Kettering Cancer Center. Previously, Dr. Toubaji has held positions as an assistant professor/staff pathologist at the George Washington University Department of Pathology.