Brid M. Ryan, Ph.D., M.P.H.
Dr. Ryan was among the first to demonstrate asymmetric division of DNA in cancer. This process is thought to underpin how tumors self-renew and regenerate. Since then, her studies have examined the roles of the tumor microenvironment and p53 in regulating this process in lung cancer. Her lab oversees an integrative and translational approach to lung cancer research, examining the genetic, environmental, and biological contributions to racial disparities in lung cancer incidence. Her research program also develops biomarkers for the early detection of lung cancer.
1) lung cancer, 2) asymmetric division, 3) molecular epidemiology, 4) health disparities, 5) small non-coding RNAs, 6) cancer biomarkers
A Dialogue on Cancer Disparities, Prevention, and Research
Our research program addresses several unanswered questions in lung cancer using an approach that integrates epidemiological, experimental and translational research. Disparities in lung cancer incidence, especially amongst men, have been evident for several decades. However, the potential etiological, genetic, and biological reasons behind these differences are underexplored and not well understood. Our laboratory investigates the science behind these health disparities and is using a multidisciplinary approach to address this question. Our laboratory is also interested in applying a biological framework to understanding the mechanism of interaction between genetics and environment with regard to lung carcinogenesis. Specifically, we have an interest in both early and adult life exposures and mechanistically understanding how they mediate lung cancer risk later in life.
Selected Key Publications
A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood..Cancer Prev Res . Dec;7(12):: 1210-8, 2014. [ Journal Article ]
- Carcinogenesis. May 28;39(6): 741-751, 2018. [ Journal Article ]
Racial and Ethnic Differences in the Relationship between Aspirin Use and Non-Small Cell Lung Cancer Risk and Survival..Cancer Epidemiol Biomarkers Prev. Aug 31. doi: 10.1158/1055-9965: 2018.
Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans..Clin Cancer Res. Dec 1;23(23): 7412-7425, 2017. [ Journal Article ]
- Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010. [ Journal Article ]
Dr. Ryan completed her undergraduate training in biochemistry at University College Cork, Ireland, in 2001. She received her Ph.D in Cancer Biology from University College Dublin and in 2005 was accepted into the NCI Cancer Prevention Fellowship Program. In 2007, she completed a Masters of Public Health at University College Dublin. She worked under the mentorship of Dr Curtis Harris during her postdoctoral training at the National Cancer Institute. In 2013, she became an NCI Earl Stadtman tenure track investigator at the NCI.
|Rony Arauz Melendez Ph.D.||Postdoctoral Fellow (iCURE)|
|Christopher E. Grant MSc.||Predoctoral Fellow (Graduate Student)|
|Emily Rossi Ph.D., MPH||Postdoctoral Fellow (CPFP)|
|Sanju Sinha B.S.||Predoctoral Fellow (Graduate Student)|
|Leila Toulabi Ph.D.||Postdoctoral Fellow (CRTA)|
|Adriana Zingone M.D., Ph.D.||Biologist|