Laboratory of Genitourinary Cancer Pathogenesis

Chief
Kathleen Kelly, Ph.D.

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

There are no Open Positions at this time, check back again later.

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

 

1) A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.

2) Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.

3) A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

4) An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging

Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

The LGCP Seminar Series runs from August to early June.  Seminars are Thursdays, 2-3 pm in the 4th floor conference room in Building 37.  Genitourinary Malignancy Center of Excellence (GUMCOE) speakers and journal clubs are in alternate locations.

Upcoming Seminars

26 Apr 2018 : Haydn Kissack (GUMCOE speaker) : "The Immunologic Niche in Urologic Cancers"

03 May 2018 : Berkley Gryder : "Drugging Cancer’s Addiction to Super Enhancers"

10 May 2018 : Remi Adelaiye-Ogala : Work in Progress Talk

07 Jun 2018 : Keith Jansson : Work in Progress Talk

Recently Completed Seminars

18 Jan 2018 : Paul Boutros  (GUMCOE speaker) : "Understanding the Origins of Tumour Aggressivity"

01 Feb 2018 : Sandra Wolin : "Taking out the Trash: Tales of RNA Surveillance"

15 Feb 2018 : Supreet Agarwal : Work in Progress Talk : “Interferon signaling confers resistance to therapy in advanced prostate cancer.”

08 Mar 2018 : Nichelle Whitlock : Work in Progress Talk : “Molecular Mechanisms of Prostate Cancer Evolution”

15 Mar 2018 : Jung-Min Lee : "Clinical development of DNA repair inhibitors in Ovarian Cancer"

05 Apr 2018 : Michael Beshiri : Work in Progress Talk :  "Cell population dynamics and mechanisms of transdifferentiation in patient-derived models of NEPC"

 

About

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

PI & Key Staff

Positions

There are no Open Positions at this time, check back again later.

Cores

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

 

1) A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.

2) Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.

3) A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

4) An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging

Please visit the LGCP Microscopy Core website for more information about our instrumentation, policies, software, techniques, publications, and how to access services. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

Contact Info

Laboratory of Genitourinary Cancer Pathogenesis
Center for Cancer Research
National Cancer Institute
Building 37, Room 1068
Bethesda, MD 20892-4263
Ph: 301-435-4651
Administrative Lab Manager
Miriam Breaugh
301-435-4652
Technical Lab Manager
Lei Fang, Ph.D.
301-402-4869