John M. Jessup, M.D.
John M. Jessup, M.D.
Adjunct Investigator

Center for Cancer Research
National Cancer Institute

Executive Plaza North (EPN), Room 6040
Rockville, MD 20892-7420
301-435-9010

The focus of Dr. Jessup's research effort currently is on cancer stem cells (CSC) in colorectal carcinoma that give rise to liver metastases. The major interest is in the role of pluripotency transcription factors in regulating quiescence, differentiation and metastasis by putative CSC. An important related scientific interest is in the mechanisms by which metastatic precursor cells survive toxic drugs or host microenvironments and approaches to ablate that resistance.

Areas of Expertise
stem cells, colorectal carcinoma

The focus of Dr. Jessup's research effort currently is on cancer stem cells (CSC) in colorectal carcinoma that give rise to liver metastases. The major interest is in the role of pluripotency transcription factors in regulating quiescence, differentiation and metastasis by putative CSC. An important related scientific interest is in the mechanisms by which metastatic precursor cells survive toxic drugs or host microenvironments and approaches to ablate that resistance.

Selected Publications
  1. Parkinson DR, McCormack RT, Keating SM, Gutman SI, Hamilton SR, Mansfield EA, Piper MA, Deverka P, Frueh FW, Jessup JM, McShane LM, Tunis SR, Sigman CC, Kelloff GJ.
    Clin Cancer Res. 20: 1428-44, 2014. [ Journal Article ]
  2. Analysis of stage and clinical/prognostic factors for colon and rectal cancer from SEER registries: AJCC and collaborative stage data collection system.
    Chen V, Hsieh M, Charlton M, Ruiz B, Karlitz J, Altekruse S, Ries L, Jessup J.
    Cancer. in press, 2014. [ Journal Article ]
  3. Zhang J, Espinoza LA, Kinders RJ, Lawrence SM, Pfister TD, Zhou M, Veenstra TD, Thorgeirsson SS, Jessup JM.
    Oncogene. 32: 4397-405, 2013. [ Journal Article ]
  4. Williams PM, Lively TG, Jessup JM, Conley BA.
    Clin Cancer Res. 18: 1531-9, 2012. [ Journal Article ]
  5. Meshinchi S, Hunger SP, Aplenc R, Adamson PC, Jessup JM.
    Clin Cancer Res . 18: 1547-54, 2012. [ Journal Article ]

J. Milburn Jessup, MD is a surgical oncologist and scientist who has joined the Laboratory of Experimental Carcinogenesis as an Adjunct Investigator in CCR. He is also Chief of the Diagnostics Evaluation Branch of the Cancer Diagnosis Program in DCTD. In 25 years of practice he focused on the multidisciplinary treatment of GI and breast cancer, melanoma and soft tissue/skeletal sarcomas in several different academic settings. He has led a research effort to study the mechanisms by which human colorectal carcinomas form hepatic metastasis and identified roles for the marker Carcinoembryonic Antigen in modulating inflammatory responses and promoting metastasis. He is currently Chair of the AJCC Hindgut Task Force that formulates the TNM staging classification in the US. He has been involved for over a decade with the American College of Surgeons Commission on Cancer and served as Chair of the National Cancer Data Committee that oversees hospital tumor registries throughout the US. Dr. Jessup also aids investigators in facilitating the development of biomarkers for clinical use in patients with cancer.

Name Position
Evgeniya Denisova Special Volunteer
Nikolay Korokhov Special Volunteer
Abid Mattoo Ph.D. Postdoctoral Fellow (Visiting)

Summary

The focus of Dr. Jessup's research effort currently is on cancer stem cells (CSC) in colorectal carcinoma that give rise to liver metastases. The major interest is in the role of pluripotency transcription factors in regulating quiescence, differentiation and metastasis by putative CSC. An important related scientific interest is in the mechanisms by which metastatic precursor cells survive toxic drugs or host microenvironments and approaches to ablate that resistance.

Areas of Expertise
stem cells, colorectal carcinoma

Research

The focus of Dr. Jessup's research effort currently is on cancer stem cells (CSC) in colorectal carcinoma that give rise to liver metastases. The major interest is in the role of pluripotency transcription factors in regulating quiescence, differentiation and metastasis by putative CSC. An important related scientific interest is in the mechanisms by which metastatic precursor cells survive toxic drugs or host microenvironments and approaches to ablate that resistance.

Publications

Selected Publications
  1. Parkinson DR, McCormack RT, Keating SM, Gutman SI, Hamilton SR, Mansfield EA, Piper MA, Deverka P, Frueh FW, Jessup JM, McShane LM, Tunis SR, Sigman CC, Kelloff GJ.
    Clin Cancer Res. 20: 1428-44, 2014. [ Journal Article ]
  2. Analysis of stage and clinical/prognostic factors for colon and rectal cancer from SEER registries: AJCC and collaborative stage data collection system.
    Chen V, Hsieh M, Charlton M, Ruiz B, Karlitz J, Altekruse S, Ries L, Jessup J.
    Cancer. in press, 2014. [ Journal Article ]
  3. Zhang J, Espinoza LA, Kinders RJ, Lawrence SM, Pfister TD, Zhou M, Veenstra TD, Thorgeirsson SS, Jessup JM.
    Oncogene. 32: 4397-405, 2013. [ Journal Article ]
  4. Williams PM, Lively TG, Jessup JM, Conley BA.
    Clin Cancer Res. 18: 1531-9, 2012. [ Journal Article ]
  5. Meshinchi S, Hunger SP, Aplenc R, Adamson PC, Jessup JM.
    Clin Cancer Res . 18: 1547-54, 2012. [ Journal Article ]

Biography

J. Milburn Jessup, MD is a surgical oncologist and scientist who has joined the Laboratory of Experimental Carcinogenesis as an Adjunct Investigator in CCR. He is also Chief of the Diagnostics Evaluation Branch of the Cancer Diagnosis Program in DCTD. In 25 years of practice he focused on the multidisciplinary treatment of GI and breast cancer, melanoma and soft tissue/skeletal sarcomas in several different academic settings. He has led a research effort to study the mechanisms by which human colorectal carcinomas form hepatic metastasis and identified roles for the marker Carcinoembryonic Antigen in modulating inflammatory responses and promoting metastasis. He is currently Chair of the AJCC Hindgut Task Force that formulates the TNM staging classification in the US. He has been involved for over a decade with the American College of Surgeons Commission on Cancer and served as Chair of the National Cancer Data Committee that oversees hospital tumor registries throughout the US. Dr. Jessup also aids investigators in facilitating the development of biomarkers for clinical use in patients with cancer.

Team

Name Position
Evgeniya Denisova Special Volunteer
Nikolay Korokhov Special Volunteer
Abid Mattoo Ph.D. Postdoctoral Fellow (Visiting)