Jianbo Chen, Ph.D.
Jianbo  Chen, Ph.D.
Staff Scientist

Dr. Chen is interested in understanding the mechanisms of virus replication and interactions of viruses with host cells. He has worked with diverse virus-host systems, from positive-strand RNA viruses to retroviruses and from yeast and plants to mammalian hosts. He is currently studying retroviral RNA trafficking, RNA packaging, and virus assembly by using live-cell imaging with advanced microscopy and image analysis.

Areas of Expertise
1) cellular and molecular biology, 2) RNA viruses and retroviruses, 3) light microscopy, 4) live-cell imaging, 5) image analysis

Contact Info

Jianbo Chen, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 535, Room 324
Frederick, MD 21702-1201
301-846-1841
chenjia@mail.nih.gov

Live-Cell Imaging and Single Molecule Tracking to Study HIV-1 Replication

I am currently studying retroviral RNA trafficking, RNA packaging, and virus assembly in human immunodeficiency virus type 1 (HIV-1) using live-cell imaging with advanced microscopy and image analysis.

Scientific Focus Areas:
Cell Biology, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry, Virology
  1. Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A. 106: 13535-40, 2009. [ Journal Article ]
  2. Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
    J. Virol. 79: 4140-9, 2005. [ Journal Article ]
  3. Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A. 101: 632-7, 2004. [ Journal Article ]
  4. Schwartz M, Chen J, Janda M, Sullivan M, den Boon J, Ahlquist P.
    Mol. Cell. 9: 505-14, 2002. [ Journal Article ]
  5. Chen J, Ahlquist P.
    J. Virol. 74: 4310-8, 2000. [ Journal Article ]

Dr. Jianbo Chen obtained his Ph.D. in virology at Kagoshima University (Japan) in 1997. He joined Dr. Paul Ahlquist's laboratory in 1997 at the Institute for Molecular Virology, University of Wisconsin-Madison, where he studied RNA replication and translation of brome mosaic virus. Dr. Chen joined the HIV Drug Resistance Program, National Cancer Institute, as a research fellow in 2002. He was promoted to a staff scientist in 2005.

Research

Live-Cell Imaging and Single Molecule Tracking to Study HIV-1 Replication

I am currently studying retroviral RNA trafficking, RNA packaging, and virus assembly in human immunodeficiency virus type 1 (HIV-1) using live-cell imaging with advanced microscopy and image analysis.

Scientific Focus Areas:
Cell Biology, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry, Virology

Publications

  1. Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A. 106: 13535-40, 2009. [ Journal Article ]
  2. Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
    J. Virol. 79: 4140-9, 2005. [ Journal Article ]
  3. Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A. 101: 632-7, 2004. [ Journal Article ]
  4. Schwartz M, Chen J, Janda M, Sullivan M, den Boon J, Ahlquist P.
    Mol. Cell. 9: 505-14, 2002. [ Journal Article ]
  5. Chen J, Ahlquist P.
    J. Virol. 74: 4310-8, 2000. [ Journal Article ]

Biography

Dr. Jianbo Chen obtained his Ph.D. in virology at Kagoshima University (Japan) in 1997. He joined Dr. Paul Ahlquist's laboratory in 1997 at the Institute for Molecular Virology, University of Wisconsin-Madison, where he studied RNA replication and translation of brome mosaic virus. Dr. Chen joined the HIV Drug Resistance Program, National Cancer Institute, as a research fellow in 2002. He was promoted to a staff scientist in 2005.