Jianbo  Chen, Ph.D.
Jianbo Chen, Ph.D.
Staff Scientist

Center for Cancer Research
National Cancer Institute

Building 535, Room 324
Frederick, MD 21702-1201
301-846-1841

Dr. Chen is interested in understanding the mechanisms of virus replication and interactions of viruses with host cells. He has worked with diverse virus-host systems, from positive-strand RNA viruses to retroviruses and from yeast and plants to mammalian hosts. He is currently studying retroviral RNA trafficking, RNA packaging, and virus assembly by using live-cell imaging with advanced microscopy and image analysis.

Areas of Expertise
cellular and molecular biology, RNA viruses and retroviruses, light microscopy, live-cell imaging, image analysis

Live cell imaging and single molecule tracking to study HIV-1 replication

Selected Publications
  1. Schwartz M, Chen J, Janda M, Sullivan M, den Boon J, Ahlquist P.
    Mol. Cell. 9: 505-14, 2002. [ Journal Article ]
  2. Chen J, Ahlquist P.
    J. Virol.. 74: 4310-8, 2000. [ Journal Article ]
  3. Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A.. 106: 13535-40, 2009. [ Journal Article ]
  4. Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
    J. Virol.. 79: 4140-9, 2005. [ Journal Article ]
  5. Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A.. 101: 632-7, 2004. [ Journal Article ]

Dr. Jianbo Chen obtained his Ph.D. in Virology at Kagoshima University (Japan) in 1997. He joined Dr. Paul Ahlquist's laboratory in 1997 at the Institute for Molecular Virology, University of Wisconsin-Madison, where he studied RNA replication and translation of brome mosaic virus. Dr. Chen joined the HIV Drug Resistance Program, National Cancer Institute, as a Research Fellow in 2002. He was promoted to a Staff Scientist in 2005.

Summary

Dr. Chen is interested in understanding the mechanisms of virus replication and interactions of viruses with host cells. He has worked with diverse virus-host systems, from positive-strand RNA viruses to retroviruses and from yeast and plants to mammalian hosts. He is currently studying retroviral RNA trafficking, RNA packaging, and virus assembly by using live-cell imaging with advanced microscopy and image analysis.

Areas of Expertise
cellular and molecular biology, RNA viruses and retroviruses, light microscopy, live-cell imaging, image analysis

Research

Live cell imaging and single molecule tracking to study HIV-1 replication

Publications

Selected Publications
  1. Schwartz M, Chen J, Janda M, Sullivan M, den Boon J, Ahlquist P.
    Mol. Cell. 9: 505-14, 2002. [ Journal Article ]
  2. Chen J, Ahlquist P.
    J. Virol.. 74: 4310-8, 2000. [ Journal Article ]
  3. Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A.. 106: 13535-40, 2009. [ Journal Article ]
  4. Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
    J. Virol.. 79: 4140-9, 2005. [ Journal Article ]
  5. Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
    Proc. Natl. Acad. Sci. U.S.A.. 101: 632-7, 2004. [ Journal Article ]

Biography

Dr. Jianbo Chen obtained his Ph.D. in Virology at Kagoshima University (Japan) in 1997. He joined Dr. Paul Ahlquist's laboratory in 1997 at the Institute for Molecular Virology, University of Wisconsin-Madison, where he studied RNA replication and translation of brome mosaic virus. Dr. Chen joined the HIV Drug Resistance Program, National Cancer Institute, as a Research Fellow in 2002. He was promoted to a Staff Scientist in 2005.