Jennifer Clare Jones, M.D., Ph.D.
Jennifer Clare Jones, M.D., Ph.D.
Assistant Clinical Investigator

Center for Cancer Research
National Cancer Institute

Building 41, Room D702B
Bethesda, MD 20892-5062
301-435-8955

Dr. Jones (McIntire) positionally cloned the TIM gene family and demonstrated the genetic association between TIMs and immune response profiles (McIntire et al., Nature Immunology 2001, and Nature 2003). As a radiation oncologist, her current research is focused on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Dr. Jones is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Areas of Expertise
1) tumor immunology, 2) radiobiology, 3) (nano) flow cytometry, 4) nanoscale particle analysis (particularly exosomes, microparticles, and other extracellular vesicles), 5) immune receptor immunogenetics and evolution, 6) vaccine and immunotherapy development

 My current research focuses on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Our laboratory is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Genetics and Genomics, Immunology
Selected Recent Publications
  1. Parker JJ, Jones JC, Strober S, Knox SJ.
    Clin Immunol. 148: 44-55, 2013. [ Journal Article ]
  2. Jones JC, Freeman GJ.
    Immunity. 38: 1083-5, 2013. [ Journal Article ]
  3. Fasola CE, Jones JC, Huang DD, Le QT, Hoppe RT, Donaldson SS.
    Int J Radiat Oncol Biol Phys. 86: 930-5, 2013. [ Journal Article ]
  4. Hiniker SM, Chen DS, Reddy S, Chang DT, Jones JC, Mollick JA, Swetter SM, Knox SJ.
    Transl Oncol. 5: 404-7, 2012. [ Journal Article ]
  5. Yao Z, Jones J, Kohrt H, Strober S.
    J Immunol. 187: 4100-8, 2011. [ Journal Article ]
Name Position
Ife Balogun Summer Student

Summary

Dr. Jones (McIntire) positionally cloned the TIM gene family and demonstrated the genetic association between TIMs and immune response profiles (McIntire et al., Nature Immunology 2001, and Nature 2003). As a radiation oncologist, her current research is focused on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Dr. Jones is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Areas of Expertise
1) tumor immunology, 2) radiobiology, 3) (nano) flow cytometry, 4) nanoscale particle analysis (particularly exosomes, microparticles, and other extracellular vesicles), 5) immune receptor immunogenetics and evolution, 6) vaccine and immunotherapy development

Research

 My current research focuses on developing immune-based therapies that synergize with radiation to produce optimal anti-tumor immune responses.

Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microparticles). Our laboratory is developing improved methods to characterize, sort, and perform functional studies of nanoparticles, and has established a flow cytometry core facility, with instrumentation for preparation, analysis, counting, and cytometric study of extracellular vesicles.

Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Genetics and Genomics, Immunology

Publications

Selected Recent Publications
  1. Parker JJ, Jones JC, Strober S, Knox SJ.
    Clin Immunol. 148: 44-55, 2013. [ Journal Article ]
  2. Jones JC, Freeman GJ.
    Immunity. 38: 1083-5, 2013. [ Journal Article ]
  3. Fasola CE, Jones JC, Huang DD, Le QT, Hoppe RT, Donaldson SS.
    Int J Radiat Oncol Biol Phys. 86: 930-5, 2013. [ Journal Article ]
  4. Hiniker SM, Chen DS, Reddy S, Chang DT, Jones JC, Mollick JA, Swetter SM, Knox SJ.
    Transl Oncol. 5: 404-7, 2012. [ Journal Article ]
  5. Yao Z, Jones J, Kohrt H, Strober S.
    J Immunol. 187: 4100-8, 2011. [ Journal Article ]

Team

Name Position
Ife Balogun Summer Student