Jane B. Trepel
Jane B. Trepel
Staff Scientist
Head, Preclinical Development Core

Center for Cancer Research
National Cancer Institute

Building 10 - Magnuson CC, Room 12N230
Bethesda, MD 20892
301-496-1547

Jane Trepel came to the NCI from the Laboratory of Preclinical Pharmacology, National Institute of Mental Health, where she identified posttranslational modification of glycoprotein hormones by ADP-ribosylation. Since then she has held positions of increasing responsibility in the former Clinical Pharmacology Branch and Medicine Branch. She is the author of five issued and pending patents in new drug development and is the recipient of a Federal Technology Transfer Award. Her interests are focused on the new therapeutic opportunities provided by molecular dissection of aberrant tumor cell signaling pathways.

Areas of Expertise
drug development
Selected Publications
  1. Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M.
    Future Med Chem. 5: 1059-71, 2013. [ Journal Article ]
  2. Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee MJ, Lee S, Vartholomaiou E, Tatokoro M, Beebe K, Miyajima N, Mohney RP, Chen Y, Hasumi H, Xu W, Fukushima H, Nakamura K, Koga F, Kihara K, Trepel J, Picard D, Neckers L.
    Proc. Natl. Acad. Sci. U.S.A.. 110: E1604-12, 2013. [ Journal Article ]
  3. Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L.
    Oncotarget. 4: 1065-74, 2013. [ Journal Article ]
  4. Korde N, Carlsten M, Lee MJ, Minter A, Tan E, Kwok M, Manasanch E, Bhutani M, Tageja N, Roschewski M, Zingone A, Costello R, Mulquin M, Zuchlinski D, Maric I, Calvo KR, Braylan R, Tembhare P, Yuan C, Stetler-Stevenson M, Trepel J, Childs R, Landgren O.
    Haematologica. 99: e81-3, 2014. [ Journal Article ]
  5. Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L.
    Mol. Cell. 53: 317-29, 2014. [ Journal Article ]

Jane Trepel came to the NCI from the Laboratory of Preclinical Pharmacology, National Institute of Mental Health, where she identified posttranslational modification of glycoprotein hormones by ADP-ribosylation. Since then she has held positions of increasing responsibility in the former Clinical Pharmacology Branch and Medicine Branch. She is the author of five issued and pending patents in new drug development and is the recipient of a Federal Technology Transfer Award. Her interests are focused on the new therapeutic opportunities provided by molecular dissection of aberrant tumor cell signaling pathways.

Name Position
Nathan Baruch Special Volunteer
Elham Fotoohabadi Special Volunteer
Ari Frosch Special Volunteer
Min-Jung Lee Ph.D. Special Volunteer
Sunmin Lee Research Chemist
Katherine Mackall Special Volunteer
Reid Schlesinger Special Volunteer
Yusuke Tomita Ph.D. Postdoctoral Fellow (Visiting)

Summary

Jane Trepel came to the NCI from the Laboratory of Preclinical Pharmacology, National Institute of Mental Health, where she identified posttranslational modification of glycoprotein hormones by ADP-ribosylation. Since then she has held positions of increasing responsibility in the former Clinical Pharmacology Branch and Medicine Branch. She is the author of five issued and pending patents in new drug development and is the recipient of a Federal Technology Transfer Award. Her interests are focused on the new therapeutic opportunities provided by molecular dissection of aberrant tumor cell signaling pathways.

Areas of Expertise
drug development

Publications

Selected Publications
  1. Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M.
    Future Med Chem. 5: 1059-71, 2013. [ Journal Article ]
  2. Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee MJ, Lee S, Vartholomaiou E, Tatokoro M, Beebe K, Miyajima N, Mohney RP, Chen Y, Hasumi H, Xu W, Fukushima H, Nakamura K, Koga F, Kihara K, Trepel J, Picard D, Neckers L.
    Proc. Natl. Acad. Sci. U.S.A.. 110: E1604-12, 2013. [ Journal Article ]
  3. Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L.
    Oncotarget. 4: 1065-74, 2013. [ Journal Article ]
  4. Korde N, Carlsten M, Lee MJ, Minter A, Tan E, Kwok M, Manasanch E, Bhutani M, Tageja N, Roschewski M, Zingone A, Costello R, Mulquin M, Zuchlinski D, Maric I, Calvo KR, Braylan R, Tembhare P, Yuan C, Stetler-Stevenson M, Trepel J, Childs R, Landgren O.
    Haematologica. 99: e81-3, 2014. [ Journal Article ]
  5. Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L.
    Mol. Cell. 53: 317-29, 2014. [ Journal Article ]

Biography

Jane Trepel came to the NCI from the Laboratory of Preclinical Pharmacology, National Institute of Mental Health, where she identified posttranslational modification of glycoprotein hormones by ADP-ribosylation. Since then she has held positions of increasing responsibility in the former Clinical Pharmacology Branch and Medicine Branch. She is the author of five issued and pending patents in new drug development and is the recipient of a Federal Technology Transfer Award. Her interests are focused on the new therapeutic opportunities provided by molecular dissection of aberrant tumor cell signaling pathways.

Team

Name Position
Nathan Baruch Special Volunteer
Elham Fotoohabadi Special Volunteer
Ari Frosch Special Volunteer
Min-Jung Lee Ph.D. Special Volunteer
Sunmin Lee Research Chemist
Katherine Mackall Special Volunteer
Reid Schlesinger Special Volunteer
Yusuke Tomita Ph.D. Postdoctoral Fellow (Visiting)