J. Carl Oberholtzer, M.D., Ph.D.
J. Carl Oberholtzer, M.D., Ph.D.
Chief
Director, Anatomic Pathology Residency Training Program

Center for Cancer Research
National Cancer Institute

Building 10, Room 2N208
Bethesda, MD 20892
301-594-1884

Dr. Oberholtzer is Chief of the Laboratory of Pathology and oversees the Laboratory’s clinical and research programs. The Laboratory provides anatomic pathology diagnostic services to investigators in the NCI and NIH, carries out basic, translational and clinical research, and trains pathology residents and research fellows.

Dr. Oberholtzer is a neuropathologist and neuroscientist, with research interests in brain tumors, as well as innovative diagnostic modalities. He also directs the ACGME-accredited training program in anatomic pathology.

Areas of Expertise
1) neuropathology 2) brain tumors 3) anatomic pathology 4) pathology training 5) peripheral auditory system
Selected Key Publications
  1. Lai JP, Liu YC, Alimchandani M, Liu Q, Aung PP, Matsuda K, Lee CC, Tsokos M, Hewitt S, Rushing EJ, Tamura D, Levens DL, Digiovanna JJ, Fine HA, Patronas N, Khan SG, Kleiner DE, Oberholtzer JC, Quezado MM, Kraemer KH.
    Acta Neuropathol Commun. 1: 4, 2013. [ Journal Article ]
  2. cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway.
    Bell TJ, Oberholtzer JC.
    J. Assoc. Res. Otolaryngol. 11: 173-85, 2010. [ Journal Article ]
  3. Li A, Walling J, Ahn S, Kotliarov Y, Su Q, Quezado M, Oberholtzer JC, Park J, Zenklusen JC, Fine HA.
    Cancer Res. 69: 2091-9, 2009. [ Journal Article ]
  4. Nelson PT, Baldwin DA, Scearce LM, Oberholtzer JC, Tobias JW, Mourelatos Z.
    Nat. Methods. 1: 155-61, 2004. [ Journal Article ]
  5. Mutai H, Kenyon LC, Locke E, Kikuchi N, Oberholtzer JC.
    BMC Genomics. 5: 90, 2004.

Dr. Oberholtzer received his B.A. and Ph.D., both in biochemistry, from the University of Pennsylvania. After completing his M.D. at Jefferson Medical College, he returned to Penn for postodoctoral training, and then residency training in Anatomic Pathology and a Fellowship in Neuropathology. Dr. Oberholtzer was on the faculty of the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine for fifteen years, most recently as Chief of the Division of Neuropathology and a Vice-Chair of the Department of Pathology and Laboratory Medicine. In addition to his clinical and administrative activities, he ran a NIH-funded molecular neuroscience laboratory in which he studied mechanisms of intrinsic frequency tuning in auditory hair cells, and signaling pathways involved in hair cell regeneration. Dr. Oberholtzer initially came to the National Cancer Institute as Associate Director for Training, a position in which he had overall responsibilities in both extramural and intramural training programs. He was appointed a Senior Clinician and Chief of the Laboratory of Pathology in 2008. Dr. Oberholtzer is a member of the American Society for Clinical Investigation, the American Association of University Pathologists (Pluto Club), and a Fellow of the College of Physicians of Philadelphia.

Name Position
Meghna Alimchandani M.D. Clinical Fellow
Michael Allgaeuer Ph.D. Clinical Fellow
Leo Ballester-Fuentes M.D., Ph.D. Clinical Fellow
Gregory Brown M.D. Clinical Fellow
Xixi Chen Summer Student
Jennifer Dreiling M.D. Clinical Fellow
Mary Eid Ph.D. Clinical Fellow
Arunima Ghosh M.D. Clinical Fellow
Terrica Johnson Histopathology Technician
Sidharth Kerkar M.D. Clinical Fellow
Drew Pratt Ph.D. Clinical Fellow
Avi Rosenberg M.D. Clinical Fellow
Hao-Wei Wang M.D. Clinical Fellow
Zhiming Yang M.D. Clinical Fellow

Summary

Dr. Oberholtzer is Chief of the Laboratory of Pathology and oversees the Laboratory’s clinical and research programs. The Laboratory provides anatomic pathology diagnostic services to investigators in the NCI and NIH, carries out basic, translational and clinical research, and trains pathology residents and research fellows.

Dr. Oberholtzer is a neuropathologist and neuroscientist, with research interests in brain tumors, as well as innovative diagnostic modalities. He also directs the ACGME-accredited training program in anatomic pathology.

Areas of Expertise
1) neuropathology 2) brain tumors 3) anatomic pathology 4) pathology training 5) peripheral auditory system

Publications

Selected Key Publications
  1. Lai JP, Liu YC, Alimchandani M, Liu Q, Aung PP, Matsuda K, Lee CC, Tsokos M, Hewitt S, Rushing EJ, Tamura D, Levens DL, Digiovanna JJ, Fine HA, Patronas N, Khan SG, Kleiner DE, Oberholtzer JC, Quezado MM, Kraemer KH.
    Acta Neuropathol Commun. 1: 4, 2013. [ Journal Article ]
  2. cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway.
    Bell TJ, Oberholtzer JC.
    J. Assoc. Res. Otolaryngol. 11: 173-85, 2010. [ Journal Article ]
  3. Li A, Walling J, Ahn S, Kotliarov Y, Su Q, Quezado M, Oberholtzer JC, Park J, Zenklusen JC, Fine HA.
    Cancer Res. 69: 2091-9, 2009. [ Journal Article ]
  4. Nelson PT, Baldwin DA, Scearce LM, Oberholtzer JC, Tobias JW, Mourelatos Z.
    Nat. Methods. 1: 155-61, 2004. [ Journal Article ]
  5. Mutai H, Kenyon LC, Locke E, Kikuchi N, Oberholtzer JC.
    BMC Genomics. 5: 90, 2004.

Biography

Dr. Oberholtzer received his B.A. and Ph.D., both in biochemistry, from the University of Pennsylvania. After completing his M.D. at Jefferson Medical College, he returned to Penn for postodoctoral training, and then residency training in Anatomic Pathology and a Fellowship in Neuropathology. Dr. Oberholtzer was on the faculty of the Department of Pathology and Laboratory Medicine at the University of Pennsylvania School of Medicine for fifteen years, most recently as Chief of the Division of Neuropathology and a Vice-Chair of the Department of Pathology and Laboratory Medicine. In addition to his clinical and administrative activities, he ran a NIH-funded molecular neuroscience laboratory in which he studied mechanisms of intrinsic frequency tuning in auditory hair cells, and signaling pathways involved in hair cell regeneration. Dr. Oberholtzer initially came to the National Cancer Institute as Associate Director for Training, a position in which he had overall responsibilities in both extramural and intramural training programs. He was appointed a Senior Clinician and Chief of the Laboratory of Pathology in 2008. Dr. Oberholtzer is a member of the American Society for Clinical Investigation, the American Association of University Pathologists (Pluto Club), and a Fellow of the College of Physicians of Philadelphia.

Team

Name Position
Meghna Alimchandani M.D. Clinical Fellow
Michael Allgaeuer Ph.D. Clinical Fellow
Leo Ballester-Fuentes M.D., Ph.D. Clinical Fellow
Gregory Brown M.D. Clinical Fellow
Xixi Chen Summer Student
Jennifer Dreiling M.D. Clinical Fellow
Mary Eid Ph.D. Clinical Fellow
Arunima Ghosh M.D. Clinical Fellow
Terrica Johnson Histopathology Technician
Sidharth Kerkar M.D. Clinical Fellow
Drew Pratt Ph.D. Clinical Fellow
Avi Rosenberg M.D. Clinical Fellow
Hao-Wei Wang M.D. Clinical Fellow
Zhiming Yang M.D. Clinical Fellow