Jianbo Chen, Ph.D.
Dr. Chen is interested in understanding the mechanisms of virus replication and interactions of viruses with host cells. He has worked with diverse virus-host systems, from positive-strand RNA viruses to retroviruses and from yeast and plants to mammalian hosts. He is currently studying retroviral RNA trafficking, RNA packaging, and virus assembly by using live-cell imaging with advanced microscopy and image analysis.
1) cellular and molecular biology, 2) RNA viruses and retroviruses, 3) light microscopy, 4) live-cell imaging, 5) image analysis
Live-Cell Imaging and Single Molecule Tracking to Study HIV-1 Replication
I am currently studying retroviral RNA trafficking, RNA packaging, and virus assembly in human immunodeficiency virus type 1 (HIV-1) using live-cell imaging with advanced microscopy and image analysis.
Selected Key Publications
High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis.Proc. Natl. Acad. Sci. U.S.A. 106: 13535-40, 2009. [ Journal Article ]
Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor.J. Virol. 79: 4140-9, 2005. [ Journal Article ]
- Proc. Natl. Acad. Sci. U.S.A. 101: 632-7, 2004. [ Journal Article ]
- Mol. Cell. 9: 505-14, 2002. [ Journal Article ]
Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a.J. Virol. 74: 4310-8, 2000. [ Journal Article ]
Dr. Jianbo Chen obtained his Ph.D. in virology at Kagoshima University (Japan) in 1997. He joined Dr. Paul Ahlquist's laboratory in 1997 at the Institute for Molecular Virology, University of Wisconsin-Madison, where he studied RNA replication and translation of brome mosaic virus. Dr. Chen joined the HIV Drug Resistance Program, National Cancer Institute, as a research fellow in 2002. He was promoted to a staff scientist in 2005.