Heidi R. Bokesch, M.S.
Staff Scientist (Contr)

Center for Cancer Research
National Cancer Institute

Building 563, Room 201
Frederick, MD 21702-1201
301-846-7409

My research focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Areas of Expertise
1) natural products, 2) chemical and spectroscopic analysis, 3) characterization of bioactive compounds

My research work focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

  1. Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    Biochem Pharmacol. 88: 313-21, 2014. [ Journal Article ]
  2. Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    PLoS One. 7: e46567, 2012. [ Journal Article ]
  3. Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC.
    Chem Pharm Bull. 59: 1178-9, 2011. [ Journal Article ]
  4. Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
    Bioorg Med Chem Lett. 20: 3848-50, 2010. [ Journal Article ]
  5. McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA.
    J Mol Biol. 369: 451-61, 2007. [ Journal Article ]

Ms. Bokesch received a M.S. in environmental biology from Hood College and a M.S. in biotechnology from Johns Hopkins University. She joined the Molecular Targets Laboratory in 1988 and is currently a staff scientist affiliated with Leidos Biomedical Research, Inc.

Summary

My research focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Areas of Expertise
1) natural products, 2) chemical and spectroscopic analysis, 3) characterization of bioactive compounds

Research

My research work focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Publications

  1. Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    Biochem Pharmacol. 88: 313-21, 2014. [ Journal Article ]
  2. Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    PLoS One. 7: e46567, 2012. [ Journal Article ]
  3. Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC.
    Chem Pharm Bull. 59: 1178-9, 2011. [ Journal Article ]
  4. Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
    Bioorg Med Chem Lett. 20: 3848-50, 2010. [ Journal Article ]
  5. McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA.
    J Mol Biol. 369: 451-61, 2007. [ Journal Article ]

Biography

Ms. Bokesch received a M.S. in environmental biology from Hood College and a M.S. in biotechnology from Johns Hopkins University. She joined the Molecular Targets Laboratory in 1988 and is currently a staff scientist affiliated with Leidos Biomedical Research, Inc.