Heidi R. Bokesch, M.S.
Staff Scientist (Contr)

Center for Cancer Research
National Cancer Institute

Building 563, Room 201
Frederick, MD 21702-1201
301-846-7409

My research work focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Areas of Expertise
natural products, spectroanalysis

My research work focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Selected Publications
  1. Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    Biochem. Pharmacol.. 88: 313-21, 2014. [ Journal Article ]
  2. Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    PLoS ONE. 7: e46567, 2012. [ Journal Article ]
  3. Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC.
    Chem. Pharm. Bull.. 59: 1178-9, 2011. [ Journal Article ]
  4. Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
    Bioorg. Med. Chem. Lett.. 20: 3848-50, 2010. [ Journal Article ]
  5. McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA.
    J. Mol. Biol.. 369: 451-61, 2007. [ Journal Article ]

Ms. Bokesch received a M.S. in environmental biology from Hood College and a M.S. in biotechnology from Johns Hopkins University. She joined the Molecular Targets Laboratory in 1988 and is currently a staff scientist affiliated with Leidos Biomedical Research, Inc.

Summary

My research work focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Areas of Expertise
natural products, spectroanalysis

Research

My research work focuses on the discovery of new natural product compounds with anticancer or anti-HIV properties. Bioassay-guided chemical fractionation of natural product extracts is employed to isolate and purify individual bioactive compounds. Chemical and spectroscopic analysis are then used to establish the complete molecular structures of the active agents. This involves the acquisition and analysis of data from a variety of contemporary spectroanalytical techniques, with a particular emphasis on NMR and mass spectrometry. Identification and structural characterization of these bioactive compounds provides new structural classes or molecular scaffolds for the development of potential drug leads or biological probes.

Publications

Selected Publications
  1. Bajer MM, Kunze MM, Blees JS, Bokesch HR, Chen H, Brauss TF, Dong Z, Gustafson KR, Biondi RM, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    Biochem. Pharmacol.. 88: 313-21, 2014. [ Journal Article ]
  2. Blees JS, Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B.
    PLoS ONE. 7: e46567, 2012. [ Journal Article ]
  3. Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, McKee TC.
    Chem. Pharm. Bull.. 59: 1178-9, 2011. [ Journal Article ]
  4. Bokesch HR, Cartner LK, Fuller RW, Wilson JA, Henrich CJ, Kelley JA, Gustafson KR, McMahon JB, McKee TC.
    Bioorg. Med. Chem. Lett.. 20: 3848-50, 2010. [ Journal Article ]
  5. McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA.
    J. Mol. Biol.. 369: 451-61, 2007. [ Journal Article ]

Biography

Ms. Bokesch received a M.S. in environmental biology from Hood College and a M.S. in biotechnology from Johns Hopkins University. She joined the Molecular Targets Laboratory in 1988 and is currently a staff scientist affiliated with Leidos Biomedical Research, Inc.