Hanqiao Feng, Ph.D.
Staff Scientist

Center for Cancer Research
National Cancer Institute

Building 37, Room 6114
Bethesda, MD 20892-4260
301-496-1581

Our studies are focused on the structural basis of how proteins like histone chaperone, liker histones, and chromatin remodelers bind to nucleosome, modulate chromatin structure, mediate the nuclear processes like DNA repair, gene transcription, and ensure accurate segregation of chromosome. We pioneered the structural determination of protein-protein complex and protein in the complex with nucleosome by high-resolution nuclear magnetic resonance (NMR) and X-ray crystallography.

Areas of Expertise
structural biology, biophysics, structural determination of protein-protein complex, protein-nucleosome complex, NMR, X-ray crystallography
Selected Publications
  1. Zhou Z, Feng H, Hansen DF, Kato H, Luk E, Freedberg DI, Kay LE, Wu C, Bai Y.
    Nat. Struct. Mol. Biol.. 15: 868-9, 2008. [ Journal Article ]
  2. Zhou Z, Feng H, Zhou BR, Ghirlando R, Hu K, Zwolak A, Miller Jenkins LM, Xiao H, Tjandra N, Wu C, Bai Y.
    Nature. 472: 234-7, 2011. [ Journal Article ]
  3. Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y.
    Science. 340: 1110-3, 2013. [ Journal Article ]
  4. Zhou BR, Feng H, Kato H, Dai L, Yang Y, Zhou Y, Bai Y.
    Proc. Natl. Acad. Sci. U.S.A.. 110: 19390-5, 2013. [ Journal Article ]
  5. Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y.
    Mol. Cell. 53: 498-505, 2014. [ Journal Article ]

Summary

Our studies are focused on the structural basis of how proteins like histone chaperone, liker histones, and chromatin remodelers bind to nucleosome, modulate chromatin structure, mediate the nuclear processes like DNA repair, gene transcription, and ensure accurate segregation of chromosome. We pioneered the structural determination of protein-protein complex and protein in the complex with nucleosome by high-resolution nuclear magnetic resonance (NMR) and X-ray crystallography.

Areas of Expertise
structural biology, biophysics, structural determination of protein-protein complex, protein-nucleosome complex, NMR, X-ray crystallography

Publications

Selected Publications
  1. Zhou Z, Feng H, Hansen DF, Kato H, Luk E, Freedberg DI, Kay LE, Wu C, Bai Y.
    Nat. Struct. Mol. Biol.. 15: 868-9, 2008. [ Journal Article ]
  2. Zhou Z, Feng H, Zhou BR, Ghirlando R, Hu K, Zwolak A, Miller Jenkins LM, Xiao H, Tjandra N, Wu C, Bai Y.
    Nature. 472: 234-7, 2011. [ Journal Article ]
  3. Kato H, Jiang J, Zhou BR, Rozendaal M, Feng H, Ghirlando R, Xiao TS, Straight AF, Bai Y.
    Science. 340: 1110-3, 2013. [ Journal Article ]
  4. Zhou BR, Feng H, Kato H, Dai L, Yang Y, Zhou Y, Bai Y.
    Proc. Natl. Acad. Sci. U.S.A.. 110: 19390-5, 2013. [ Journal Article ]
  5. Hong J, Feng H, Wang F, Ranjan A, Chen J, Jiang J, Ghirlando R, Xiao TS, Wu C, Bai Y.
    Mol. Cell. 53: 498-505, 2014. [ Journal Article ]