Girma M. Woldemichael, Ph.D.
Staff Scientist (Contr)

Center for Cancer Research
National Cancer Institute

Building 538, Room 131
Frederick, MD 21702-1201
301-846-5556

High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.

Areas of Expertise
high-throughput screening

High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.

Selected Publications
  1. Giubellino A, Woldemichael GM, Sourbier C, Lizak MJ, Powers JF, Tischler AS, Pacak K.
    Cancer Lett.. 316: 46-52, 2012. [ Journal Article ]
  2. Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, McMahon JB.
    Neoplasia. 14: 771-7, 2012. [ Journal Article ]
  3. Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB.
    Cancer Res.. 71: 134-42, 2011. [ Journal Article ]
  4. Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ.
    J. Natl. Cancer Inst.. 103: 962-78, 2011. [ Journal Article ]
  5. Meragelman TL, Willis RH, Woldemichael GM, Heaton A, Murphy PT, Snader KM, Newman DJ, van Soest R, Boyd MR, Cardellina JH, McKee TC.
    J. Nat. Prod.. 70: 1133-8, 2007. [ Journal Article ]

Received a Ph.D. in Pharmaceutical Chemical Biology from Heidelberg University (Germany) and did post-doctoral research at the University of Arizona and at the NCI. Joined the Molecular Targets Development Program in 2007 as a Staff Scientist affiliated with Leidos-Frederick, Inc.

Summary

High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.

Areas of Expertise
high-throughput screening

Research

High throughput screening represents an attractive route for the discovery of modulators of newly discovered targets in cancer and other diseases. An area of my research focus is the development of validated cell-based high throughput screening assays for the discovery of modulators of such targets. Emphasis is given to discovery of modulators from natural products (plants, marine- and micro-organisms) through the design of natural products compatible screening assays. The biological characterization of screen hits through the elucidation mechanisms and/or modes of action is another area of my research focus. My work encompasses the intersection of various disciplines including natural products chemistry, molecular and cellular biology,and high throughput automation.

Publications

Selected Publications
  1. Giubellino A, Woldemichael GM, Sourbier C, Lizak MJ, Powers JF, Tischler AS, Pacak K.
    Cancer Lett.. 316: 46-52, 2012. [ Journal Article ]
  2. Woldemichael GM, Turbyville TJ, Vasselli JR, Linehan WM, McMahon JB.
    Neoplasia. 14: 771-7, 2012. [ Journal Article ]
  3. Woldemichael GM, Turbyville TJ, Linehan WM, McMahon JB.
    Cancer Res.. 71: 134-42, 2011. [ Journal Article ]
  4. Grohar PJ, Woldemichael GM, Griffin LB, Mendoza A, Chen QR, Yeung C, Currier DG, Davis S, Khanna C, Khan J, McMahon JB, Helman LJ.
    J. Natl. Cancer Inst.. 103: 962-78, 2011. [ Journal Article ]
  5. Meragelman TL, Willis RH, Woldemichael GM, Heaton A, Murphy PT, Snader KM, Newman DJ, van Soest R, Boyd MR, Cardellina JH, McKee TC.
    J. Nat. Prod.. 70: 1133-8, 2007. [ Journal Article ]

Biography

Received a Ph.D. in Pharmaceutical Chemical Biology from Heidelberg University (Germany) and did post-doctoral research at the University of Arizona and at the NCI. Joined the Molecular Targets Development Program in 2007 as a Staff Scientist affiliated with Leidos-Frederick, Inc.