Giorgio  Trinchieri, M.D.
Giorgio Trinchieri, M.D.
Program Director
Chief, Laboratory of Experimental Immunology
Head, Cancer Immunobiology Section

Center for Cancer Research
National Cancer Institute

Building 560, Room 31-93
Frederick, MD 21702-1201
301-846-1323

Dr. Trinchieri has contributed to the identification of the interplay between inflammation/innate resistance and adaptive immunity, and of the role of cytokines and interferons in the regulation of hematopoiesis, innate resistance and immunity in infections and cancer. His main focus is now the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression, and therapy of cancer.

As CIP director, Dr. Trinchieri oversees the operations of two intramural laboratories that constitute the major immunologic component of the NCI inflammation and cancer initiative that seeks to partner NCI’s expertise in inflammation and immunology with its cutting-edge cancer etiology and carcinogenesis program.

Areas of Expertise
1) inflammation, 2) microbiota, 3) carcinogenesis, 4) cytokines, 5) interleukin-12, 6) interferons

Role of Inflammation, Innate Resistance, and Immunity in Carcinogenesis, Cancer Progression, and Prevention or Destruction

Recent studies are shedding quite a different light on the way in which innate resistance, as an integral part of inflammation, is participating in oncogenesis and tumor surveillance. For a long time, innate resistance has been considered a primitive non-specific form of resistance to infections eclipsed by the potent and specific acquired immunity of higher organisms. More recently, it has been recognized that innate resistance is not only the first line of defense against infections but it sets the stage and it is necessary for the development of adaptive immunity. It is now becoming evident, however, that the processes that the organisms use for resistance to infections are derived and shared with the mechanisms essential for tissue homeostasis and morphogenesis. Innate resistance is mediated not only by specialized cells but most stromal and parenchyma cells participate in the process and they may express and utilize many of the receptors also utilized by "immune cells" with similar signaling and physiological responses. Similarly, in cancer biology, it is becoming manifest that what used to be considered the defensive mechanisms of innate resistance and inflammation are indeed manifestations of tissue homeostasis and control of cellular proliferation that have many pleiotropic effects on carcinogenesis and tumor progression and dissemination. The interaction of the inflammatory mediators and effector cells with carcinogenesis and tumor progression is complicated and results in effects that either favor or impede tumor progression. The simple concept that early inflammation is necessary for carcinogenesis whereas inflammatory and immune response would prevent, when successful, tumor progression has being replaced by a more subtle understanding that the degree of inflammation and the type of inflammatory/immune response are responsible for tilting the balance between tumor progression and regression. The different investigators of the Cancer and Inflammation Program (CIP), also in collaboration with many investigators focusing in carcinogenesis and tumor biology, both in Bethesda and in Frederick, will be investigating many aspects of the complex cross-talk between inflammation and cancer.

In my own group and in collaboration with the other investigators in the CIP, I plan to pursue a scientific program both in the mouse and in humans on the interface between inflammation, natural resistance and adaptive immunity with a focus on:

1) The molecular and cellular mechanisms regulating the activity of dendritic cell subsets, particularly the type I Interferon-producing plasmacytoid dendritic cells as well as conventional dendritic cells and their cross-activating interaction with other inflammatory cell types, natural killer (NK) cells, and T cells.

2) The role of plasmacytoid dendritic cells in the regulation of immune response and tolerance in experimental models of cancer, autoimmunity, and infections.

3) The study of the molecular, structural and signaling aspects of receptors recognizing pathogens, particularly Toll-like receptors, cytoplasmic NOD and RIG-I-like receptors, and other surface receptor and their synergism/antagonism in the regulation of the inflammatory response.

4) The role of cytokines (including IL-12 family, type I and II interferons, interleukin-10) and dendritic cells in regulating the early innate response to infections and cancer and the deviation of the adaptive response for the development of preventive (vaccines) and prophylactic treatments for cancer and infectious diseases.

5) The study of the immunosuppressive tumor environment resulting in alternate activation of macrophages and myeloid cells and paralysis of dendritic cells, with an emphasis on the role of IL-10 and STAT3 activation; the reversion of the immunosuppressive environment will be combined to activation of innate resistance or modulation of the inflammatory response for anti-tumor therapy.

6) The role of various inflammation-related gene products (tumor necrosis factor, IL-12, IL-23, IL-27, IL-10, IL-17, IL-22, Toll-like receptors and their signaling molecules) in carcinogenesis utilizing various genetic or chemical models of colon and skin carcinogenesis.

Scientific Focus Areas:
Cancer Biology, Immunology, Microbiology and Infectious Diseases, Virology
  1. Stewart CA, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, Leighty RM, Roers A, Karp CL, Müller W, Trinchieri G.
    J. Clin. Invest. 123: 4859-74, 2013. [ Journal Article ]
  2. Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
    Science. 342: 967-70, 2013. [ Journal Article ]
  3. Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A.
    Immunity. 36: 1047-59, 2012. [ Journal Article ]
  4. Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.
    J. Exp. Med. 209: 1689-702, 2012. [ Journal Article ]
  5. Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
    J. Exp. Med. 207: 1625-36, 2010. [ Journal Article ]

Dr. Trinchieri was most recently the Director of the Schering Plough Laboratory for Immunological Research in Dardilly, France, and an NIH Fogarty Scholar at the Laboratory for Parasitic Diseases, NIAID. Since August 2006, he has been the Director of the Cancer and Inflammation Program, and Chief of the Laboratory of Experimental Immunology. His research at the CCR focuses on the interplay between inflammation/innate resistance and adaptive immunity, and the role of pro-inflammatory cytokines in the regulation of hematopoiesis, innate resistance, and immunity. He discovered interleukin-12 while at the Wistar Institute in 1989 and for many years has been characterizing the molecular mechanisms of interleukin-12 production and action, and the role of this molecule in tumor immunity, infections, and autoimmunity.

Name Position
Stephen K. Anderson, Ph.D. Senior Investigator (Contr)
Jonathan H. Badger, Ph.D. Staff Scientist
Maria Clavijosalomon Postdoctoral Fellow (Visiting)
Sarah Cramer Postdoctoral Fellow (CRTA)
Ren-Meng Dai Laboratory Technician (Contr)
Michael Dean, Ph.D. Deputy Program Director
Scott K. Durum, Ph.D. Deputy Laboratory Chief
Amiran K. Dzutsev M.D., Ph.D. Staff Scientist (Contr)
Romina Silvana Goldszmid Ph.D. Staff Scientist
Arthur Hurwitz Ph.D. Investigator
Dennis M. Klinman, M.D., Ph.D. Senior Investigator
Daniel W. McVicar, Ph.D. Senior Investigator
Kathleen B. Noer, B.A. Staff Scientist (Contr)
Colm S. O'Huigin, Ph.D. Staff Scientist (Contr)
Joost J. Oppenheim, M.D. Deputy Program Director
Soumen Roy Pre-doctoral Fellow (CRTA)
Rosalba Salcedo, Ph.D. Staff Scientist
Heliosworth Sales de Campos Predoctoral Fellow (Contr.)
Shakir Saud Special Volunteer
Thomas J. Sayers, Ph.D. Senior Investigator (Contr)
Loretta Smith Biological Laboratory Technician
Robert H. Wiltrout, Ph.D. Senior Investigator
Robin Winkler-Pickett Research Biologist
Howard A. Young, Ph.D. Deputy Laboratory Chief

Summary

Dr. Trinchieri has contributed to the identification of the interplay between inflammation/innate resistance and adaptive immunity, and of the role of cytokines and interferons in the regulation of hematopoiesis, innate resistance and immunity in infections and cancer. His main focus is now the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression, and therapy of cancer.

As CIP director, Dr. Trinchieri oversees the operations of two intramural laboratories that constitute the major immunologic component of the NCI inflammation and cancer initiative that seeks to partner NCI’s expertise in inflammation and immunology with its cutting-edge cancer etiology and carcinogenesis program.

Areas of Expertise
1) inflammation, 2) microbiota, 3) carcinogenesis, 4) cytokines, 5) interleukin-12, 6) interferons

Research

Role of Inflammation, Innate Resistance, and Immunity in Carcinogenesis, Cancer Progression, and Prevention or Destruction

Recent studies are shedding quite a different light on the way in which innate resistance, as an integral part of inflammation, is participating in oncogenesis and tumor surveillance. For a long time, innate resistance has been considered a primitive non-specific form of resistance to infections eclipsed by the potent and specific acquired immunity of higher organisms. More recently, it has been recognized that innate resistance is not only the first line of defense against infections but it sets the stage and it is necessary for the development of adaptive immunity. It is now becoming evident, however, that the processes that the organisms use for resistance to infections are derived and shared with the mechanisms essential for tissue homeostasis and morphogenesis. Innate resistance is mediated not only by specialized cells but most stromal and parenchyma cells participate in the process and they may express and utilize many of the receptors also utilized by "immune cells" with similar signaling and physiological responses. Similarly, in cancer biology, it is becoming manifest that what used to be considered the defensive mechanisms of innate resistance and inflammation are indeed manifestations of tissue homeostasis and control of cellular proliferation that have many pleiotropic effects on carcinogenesis and tumor progression and dissemination. The interaction of the inflammatory mediators and effector cells with carcinogenesis and tumor progression is complicated and results in effects that either favor or impede tumor progression. The simple concept that early inflammation is necessary for carcinogenesis whereas inflammatory and immune response would prevent, when successful, tumor progression has being replaced by a more subtle understanding that the degree of inflammation and the type of inflammatory/immune response are responsible for tilting the balance between tumor progression and regression. The different investigators of the Cancer and Inflammation Program (CIP), also in collaboration with many investigators focusing in carcinogenesis and tumor biology, both in Bethesda and in Frederick, will be investigating many aspects of the complex cross-talk between inflammation and cancer.

In my own group and in collaboration with the other investigators in the CIP, I plan to pursue a scientific program both in the mouse and in humans on the interface between inflammation, natural resistance and adaptive immunity with a focus on:

1) The molecular and cellular mechanisms regulating the activity of dendritic cell subsets, particularly the type I Interferon-producing plasmacytoid dendritic cells as well as conventional dendritic cells and their cross-activating interaction with other inflammatory cell types, natural killer (NK) cells, and T cells.

2) The role of plasmacytoid dendritic cells in the regulation of immune response and tolerance in experimental models of cancer, autoimmunity, and infections.

3) The study of the molecular, structural and signaling aspects of receptors recognizing pathogens, particularly Toll-like receptors, cytoplasmic NOD and RIG-I-like receptors, and other surface receptor and their synergism/antagonism in the regulation of the inflammatory response.

4) The role of cytokines (including IL-12 family, type I and II interferons, interleukin-10) and dendritic cells in regulating the early innate response to infections and cancer and the deviation of the adaptive response for the development of preventive (vaccines) and prophylactic treatments for cancer and infectious diseases.

5) The study of the immunosuppressive tumor environment resulting in alternate activation of macrophages and myeloid cells and paralysis of dendritic cells, with an emphasis on the role of IL-10 and STAT3 activation; the reversion of the immunosuppressive environment will be combined to activation of innate resistance or modulation of the inflammatory response for anti-tumor therapy.

6) The role of various inflammation-related gene products (tumor necrosis factor, IL-12, IL-23, IL-27, IL-10, IL-17, IL-22, Toll-like receptors and their signaling molecules) in carcinogenesis utilizing various genetic or chemical models of colon and skin carcinogenesis.

Scientific Focus Areas:
Cancer Biology, Immunology, Microbiology and Infectious Diseases, Virology

Publications

  1. Stewart CA, Metheny H, Iida N, Smith L, Hanson M, Steinhagen F, Leighty RM, Roers A, Karp CL, Müller W, Trinchieri G.
    J. Clin. Invest. 123: 4859-74, 2013. [ Journal Article ]
  2. Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
    Science. 342: 967-70, 2013. [ Journal Article ]
  3. Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A.
    Immunity. 36: 1047-59, 2012. [ Journal Article ]
  4. Cataisson C, Salcedo R, Hakim S, Moffitt BA, Wright L, Yi M, Stephens R, Dai RM, Lyakh L, Schenten D, Yuspa HS, Trinchieri G.
    J. Exp. Med. 209: 1689-702, 2012. [ Journal Article ]
  5. Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
    J. Exp. Med. 207: 1625-36, 2010. [ Journal Article ]

Biography

Dr. Trinchieri was most recently the Director of the Schering Plough Laboratory for Immunological Research in Dardilly, France, and an NIH Fogarty Scholar at the Laboratory for Parasitic Diseases, NIAID. Since August 2006, he has been the Director of the Cancer and Inflammation Program, and Chief of the Laboratory of Experimental Immunology. His research at the CCR focuses on the interplay between inflammation/innate resistance and adaptive immunity, and the role of pro-inflammatory cytokines in the regulation of hematopoiesis, innate resistance, and immunity. He discovered interleukin-12 while at the Wistar Institute in 1989 and for many years has been characterizing the molecular mechanisms of interleukin-12 production and action, and the role of this molecule in tumor immunity, infections, and autoimmunity.

Team

Name Position
Stephen K. Anderson, Ph.D. Senior Investigator (Contr)
Jonathan H. Badger, Ph.D. Staff Scientist
Maria Clavijosalomon Postdoctoral Fellow (Visiting)
Sarah Cramer Postdoctoral Fellow (CRTA)
Ren-Meng Dai Laboratory Technician (Contr)
Michael Dean, Ph.D. Deputy Program Director
Scott K. Durum, Ph.D. Deputy Laboratory Chief
Amiran K. Dzutsev M.D., Ph.D. Staff Scientist (Contr)
Romina Silvana Goldszmid Ph.D. Staff Scientist
Arthur Hurwitz Ph.D. Investigator
Dennis M. Klinman, M.D., Ph.D. Senior Investigator
Daniel W. McVicar, Ph.D. Senior Investigator
Kathleen B. Noer, B.A. Staff Scientist (Contr)
Colm S. O'Huigin, Ph.D. Staff Scientist (Contr)
Joost J. Oppenheim, M.D. Deputy Program Director
Soumen Roy Pre-doctoral Fellow (CRTA)
Rosalba Salcedo, Ph.D. Staff Scientist
Heliosworth Sales de Campos Predoctoral Fellow (Contr.)
Shakir Saud Special Volunteer
Thomas J. Sayers, Ph.D. Senior Investigator (Contr)
Loretta Smith Biological Laboratory Technician
Robert H. Wiltrout, Ph.D. Senior Investigator
Robin Winkler-Pickett Research Biologist
Howard A. Young, Ph.D. Deputy Laboratory Chief