Christian S. Hinrichs, M.D.

Christian S. Hinrichs, M.D.
Senior Investigator
Genitourinary Malignancies Branch

Dr. Hinrichs researches immunotherapy for HPV+ cancers, which include cervical, oropharyngeal, anal, vulvar, vaginal, and penile malignancies. He has discovered personalized cellular and gene therapies for HPV+ cancers. His laboratory is studying why these treatments work in some patients and not in others and is using what is learned to innovate more effective therapies.

Areas of Expertise

1) immunotherapy, 2) cell therapy, 3) human papillomavirus, 4) cervical cancer, 5) oropharyngeal cancer, 6) anal cancer

Contact Info

Christian S. Hinrichs, M.D.
Center for Cancer Research
National Cancer Institute
Building 10, Room 4B04
Bethesda, MD 20892
Ph: 240-760-6059
Fax: 240-541-4541
hinrichs@mail.nih.gov

Cellular Therapy for Cancer

Dr. Hinrichs conducts basic and clinical research to discover and develop novel T cell therapies for the treatment of patients with cancer. This work includes a clinical trial of human papillomavirus (HPV)-targeted tumor-infiltrating T cells for patients with HPV+ cancers, which has demonstrated that this treatment can mediate complete regression of cervical cancer in some patients. Dr. Hinrichs' laboratory also has discovered genes for T cell receptors that target HPV, and his group is testing new gene therapy treatments based on these receptors for patients with advanced HPV+ tumors.

NIH Scientific Focus Areas:
Biomedical Engineering and Biophysics, Cancer Biology, Clinical Research, Immunology, Virology
View Dr. Hinrichs' PubMed Summary.

Selected Recent Publications

  1. T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study.
    Doran SL, Stevanović S, Adhikary S, Gartner JJ, Jia L, Kwong MLM, Faquin WC, Hewitt SM, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.
    J Clin Oncol. 37(30): 2759-68, 2019. [ Journal Article ]
  2. A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers.
    Stevanović S, Helman SR, Wunderlich JR, Langhan MM, Doran SL, Kwong MLM, Somerville RPT, Klebanoff CA, Kammula US, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.
    Clin Cancer Res. 25(5): 1486-93, 2019. [ Journal Article ]
  3. Cell-based molecularly targeted therapy: targeting oncoproteins with T cell receptor gene therapy.
    Hinrichs CS
    J Clin Invest. 128(4): 1261-63, 2018. [ Journal Article ]
  4. Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer.
    Stevanović S, Pasetto A, Helman SR, Gartner JJ, Prickett TD, Howie B, Robins HS, Robbins PF, Klebanoff CA, Rosenberg SA, Hinrichs CS.
    Science. 356(6334): 200-205, 2017. [ Journal Article ]
  5. Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6..
    Draper LM, Kwong ML, Gros A, Stevanovic S, Tran E, Kerkar S, Raffeld M, Rosenberg SA, Hinrichs CS
    Clin Cancer Res. 21(19): 4431-9, 2015. [ Journal Article ]

Dr. Hinrichs received his B.A. and M.D. degrees from the combined 6-year program at the University of Missouri - Kansas City (UMKC). He trained in general surgery at UMKC and in surgical oncology at Roswell Park Cancer Institute. He then completed a surgical oncology and tumor immunology fellowship at the National Cancer Institute (NCI). Subsequently he trained in internal medicine at George Washington University and in medical oncology at the Medical Oncology Branch of the NCI. He was awarded tenure at NIH in 2020. Dr. Hinrichs conducts basic research and clinical research to develop T-cell therapies for HPV-associated cancers and other epithelial malignancies.

Name Position
Pradip Bajgain Ph.D. Postdoctoral Fellow (Visiting)
James (Xinle) Cui M.D., Ph.D. Scientist (Contr.)
John Davies Ph.D. Postdoctoral Fellow (CRTA)
Erin Ferraro Research Nurse Coordinator
Deane Francia Administrative Assistant (Contr.)
Nikolaos Gkitsas Biologist (Contr.)
Tejas B. Kadakia Ph.D. Scientist (Contr.)
Farrah Karimipour Postbaccalaureate Fellow (CRTA)
Megan Kenyon Physician Assistant
Soumya Korrapati Ph.D. Scientist (Contr.)
Xiang Liu Ph.D. Scientist (Contr.)
Bridget Marcinkowski B.S. Special Volunteer
Erik Martin Ph.D. Scientist (Contr.)
Lotte Mousset Ph.D., B.D. Postdoctoral Fellow (Visiting)
Nisha Nagarsheth Ph.D. Postdoctoral Fellow (CRTA)
Scott M. Norberg, D.O. Assistant Research Physician
Carylinda Serna Biologist (Contr.)
Andrew Sinkoe Ph.D. Postdoctoral Fellow (CRTA)
Ling Zhang Ph.D. Biologist

For Researchers

Plasmids

Christian Hinrichs Lab Plasmids - Our lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research.

Protocols

SOP-D-001 - 293GP Retroviral Production

SOP-D-002 - Retroviral Transduction of Human T Cells

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We are NIH
Immunotherapy Clinical Trials: Sue Scott's Story of Survival video
Immunotherapy Clinical Trials: Sue Scott's Story of Survival
Clinical trial will test immunotherapy for type of HPV infection
Clinical trial will test immunotherapy for type of HPV infection