The Experimental Transplantation and Immunotherapy Branch is dedicated to coordinated efforts in basic, preclinical and clinical investigations in the areas of immunotherapy, immune reconstitution, T cell biology, hematopoiesis, and hematopoietic stem cell transplantation. The goal is to generate information from basic and preclinical investigations to develop new, curative hematopoietic stem cell transplant-based therapies for cancer. Information from new treatment protocols (including novel endpoints generated in the course of basic/preclinical research) is used to generate new questions and studies in the basic and preclinical research efforts. The branch emphasizes excellence in these endeavors and acts to maximize strengths present in the community at large by vigorous intramural and extramural interactions and collaborations.
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A Phase 1/1b Study of Enhancement of Immune Reconstitution and Vaccine Responses with Administration of Recombinant Human IL-7-hyFc (NT-I7) in Older Subjects Following Chemotherapy
Open - RecruitingNCI Protocol ID NCI-19-C-0134Investigator Ronald E. Gress, M.D. -
Phase I/II Study De-intensifying Exposure of Post-transplantation Cyclophosphamide as GVHD Prophylaxis after HLA-haploidentical Hematopoietic Cell Transplantation for Hematologic Malignancies
Open - RecruitingNCI Protocol ID NCI-19-C-0112Investigator Christopher G. Kanakry, M.D. -
Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell Lymphoma
Open - RecruitingNCI Protocol ID NCI-19-C-0085Investigator Jennifer A. Kanakry, M.D. -
Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
Open - RecruitingNCI Protocol ID NCI-18-C-0135Investigator Jennifer A. Kanakry, M.D. -
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Open - RecruitingNCI Protocol ID NCI-16-C-0003Investigator Jennifer A. Kanakry, M.D. -
Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR-105) for the Treatment of Patients with Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant
Open - Not yet RecruitingNCI Protocol ID NCI-00-0-021Investigator Jennifer A. Kanakry, M.D.
| Position | Degree Required | Contact Name | E-mail Address |
|---|---|---|---|
| Patient Care Coordinator - healthcare, clinic support | N/A | Lauri Rimorin | Lauri.Rimorin@nih.gov |
| Post-doctoral Fellow - Hematopoietic Cell Transplantation Immunology | Ph.D. or equivalent, M.D. or equivalent | Christopher Kanakry | christopher.kanakry@nih.gov |
ETIB Clinical Core
Personnel in this core group provide the infrastructural expertise for excellence in patient care and clinical research within the Branch.
Judy L. Baruffaldi, Patient Care Coordinator (Contr.)
Melissa Cardoso, Patient Care Coordinator (Contr.)
Tracey Chinn, RN, BSN, MPM, Head, Clinical Studies Unit
Richard Kwan, M.S., Physician Assistant
Christi McKeown, B.S.N., M.S.N., Nurse practitioner
Sarfraz A. Memon, M.D., Research Chemist
Scott Napier, PA-C, Physician Assistant
Eun Soo Paek, RN, BSN, Clinical Apheresis Nurse
Laura Skeffington, B.S., Physician Assistant (Contr.)
Jen Sponaugle, M.B.S., Physician Assistant
Anita Stokes, CRNP, Nurse Practitioner
Jennifer Wilders, RN, Nurse Specialist (Contr.)
About
The Experimental Transplantation and Immunotherapy Branch is dedicated to coordinated efforts in basic, preclinical and clinical investigations in the areas of immunotherapy, immune reconstitution, T cell biology, hematopoiesis, and hematopoietic stem cell transplantation. The goal is to generate information from basic and preclinical investigations to develop new, curative hematopoietic stem cell transplant-based therapies for cancer. Information from new treatment protocols (including novel endpoints generated in the course of basic/preclinical research) is used to generate new questions and studies in the basic and preclinical research efforts. The branch emphasizes excellence in these endeavors and acts to maximize strengths present in the community at large by vigorous intramural and extramural interactions and collaborations.
Clinical Trials
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A Phase 1/1b Study of Enhancement of Immune Reconstitution and Vaccine Responses with Administration of Recombinant Human IL-7-hyFc (NT-I7) in Older Subjects Following Chemotherapy
Open - RecruitingNCI Protocol ID NCI-19-C-0134Investigator Ronald E. Gress, M.D. -
Phase I/II Study De-intensifying Exposure of Post-transplantation Cyclophosphamide as GVHD Prophylaxis after HLA-haploidentical Hematopoietic Cell Transplantation for Hematologic Malignancies
Open - RecruitingNCI Protocol ID NCI-19-C-0112Investigator Christopher G. Kanakry, M.D. -
Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Peripheral T cell Lymphoma
Open - RecruitingNCI Protocol ID NCI-19-C-0085Investigator Jennifer A. Kanakry, M.D. -
Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation
Open - RecruitingNCI Protocol ID NCI-18-C-0135Investigator Jennifer A. Kanakry, M.D. -
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies
Open - RecruitingNCI Protocol ID NCI-16-C-0003Investigator Jennifer A. Kanakry, M.D. -
Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR-105) for the Treatment of Patients with Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant
Open - Not yet RecruitingNCI Protocol ID NCI-00-0-021Investigator Jennifer A. Kanakry, M.D.
PI & Key Staff
Positions
| Position | Degree Required | Contact Name | E-mail Address |
|---|---|---|---|
| Patient Care Coordinator - healthcare, clinic support | N/A | Lauri Rimorin | Lauri.Rimorin@nih.gov |
| Post-doctoral Fellow - Hematopoietic Cell Transplantation Immunology | Ph.D. or equivalent, M.D. or equivalent | Christopher Kanakry | christopher.kanakry@nih.gov |
Cores
ETIB Clinical Core
Personnel in this core group provide the infrastructural expertise for excellence in patient care and clinical research within the Branch.
Judy L. Baruffaldi, Patient Care Coordinator (Contr.)
Melissa Cardoso, Patient Care Coordinator (Contr.)
Tracey Chinn, RN, BSN, MPM, Head, Clinical Studies Unit
Richard Kwan, M.S., Physician Assistant
Christi McKeown, B.S.N., M.S.N., Nurse practitioner
Sarfraz A. Memon, M.D., Research Chemist
Scott Napier, PA-C, Physician Assistant
Eun Soo Paek, RN, BSN, Clinical Apheresis Nurse
Laura Skeffington, B.S., Physician Assistant (Contr.)
Jen Sponaugle, M.B.S., Physician Assistant
Anita Stokes, CRNP, Nurse Practitioner
Jennifer Wilders, RN, Nurse Specialist (Contr.)
Contact Info
Center for Cancer Research
National Cancer Institute
Building 10, Room 3E3330
Bethesda, MD 20892-1203
Ph: 240-858-3030
Fax: 240-541-4566