Electron Kebebew, M.D., F.A.C.S.

Electron  Kebebew, M.D., F.A.C.S
Chief
Senior Investigator
Head, Endocrine Oncology Branch Laboratory

Dr. Kebebew and his team investigate the genomic changes associated with endocrine cancers with the ultimate goal of identifying therapeutic targets and novel anticancer agents for endocrine cancers, and diagnostic and prognostic markers for endocrine tumors. Dr. Kebebew is a Fellow of the American College of Surgeons, an internationally recognized expert in endocrine surgery, and has performed more than 3,000 operations on the adrenal, pancreas, parathyroid and thyroid.

Areas of Expertise
1) endocrine cancers, 2) thyroid cancer, 3) adrenal cancer, 4) neuroendocrine tumor

Contact Info

Electron Kebebew, M.D., F.A.C.S.
Center for Cancer Research
National Cancer Institute
Building 10 - Hatfield CRC, Room 4-5952
Bethesda, MD 20892-1201
Ph: 301-496-5049
kebebewe@mail.nih.gov

Our research is focused on understanding the genetic/genomic/epigenetic changes that drive endocrine cancer growth and metastases, and to use this knowledge to improve diagnosis and prognostication, and treatment for these cancers. Currently, we have three main areas of investigations: 1) identification of altered pathways in endocrine neoplasms using pangenomic analysis of human samples and characterizing the functions of these altered genes/pathways using in vitro and in vivo models, 2) discovery of therapeutic targets and novel anticancer agents for endocrine cancers, and 3) genetic studies in familial non-medullary thyroid cancer to identify the susceptibility gene(s) and its application to improve screening and diagnosis of at-risk individuals.

Scientific Focus Areas:
Cancer Biology, Clinical Research, Genetics and Genomics
View Dr. Kebebew's PubMed Summary.

Selected Recent Publications

  1. Liu-Chittenden Y, Jain M, Gaskins K, Wang S, Merino MJ, Kotian S, Kumar Gara S, Davis S, Zhang L, Kebebew E.
    Oncogene. 2017. [ Journal Article ]
  2. Boufraqech M, Zhang L, Nilubol N, Sadowski SM, Kotian S, Quezado M, Kebebew E
    Clin Cancer Res. 22: 4491-4504, 2016. [ Journal Article ]
  3. Sadowski SM, Neychev V, Millo C, Shih J, Nilubol N, Herscovitch P, Pacak K, Marx SJ, Kebebew E.
    J. Clin Oncol. 34: 588-596, 2016. [ Journal Article ]
  4. Satoh K, Zhang L, Zhang Y, Chelluri R, Boufraqech M, Nilubol N, Patel D, Shen M, Kebebew E.
    Clin Cancer Res. 22/14: 3458-3466, 2016. [ Journal Article ]
  5. Zheng S, Cherniack AD, Dewal N, Moffitt RA, Danilova L, Murray BA, Lerario AM, Else T, Knijnenburg TA, Ciriello G, Kim S, Assie G, Morozova O, Akbani R, Shih J, Hoadley KA, Choueiri TK, Waldmann J, Mete O, Robertson AG, Wu HT, Raphael BJ, Shao L, Meyerson M, Demeure MJ, Beuschlein F, Gill AJ, Sidhu SB, Almeida MQ, Fragoso MC, Cope LM, Kebebew E, Habra MA, Whitsett TG, Bussey KJ, Rainey WE, Asa SL, Bertherat J, Fassnacht M, Wheeler DA, Cancer Genome Atlas Research N, Hammer GD, Giordano TJ, Verhaak RG.
    Cancer Cell. 29/5: 723-736, 2016. [ Journal Article ]

Dr. Kebebew received his bachelor's degree from the University of California, Los Angeles, in chemical engineering. He completed his medical training, surgical residency and NCI T32 Surgical Oncology Basic Science fellowship at the University of California, San Francisco. Dr. Kebebew joined the surgical faculty at the University of California, San Francisco, in 2002. In 2009, Dr. Kebebew was recruited to be the Head of the Endocrine Oncology Section in the Surgery Branch. In 2012, he became Chief of the newly established Endocrine Oncology Branch. Dr. Kebebew has published over 300 articles, chapters and textbooks. He has received awards from the American Cancer Society, American Association for Cancer Research, American Thyroid Association, American Association of Endocrine Surgeons, and International Association of Endocrine Surgeons. His laboratory investigates the genetic/genomic changes associated with endocrine cancers with the ultimate goal of identifying therapeutic targets and novel anticancer agents for endocrine cancers, and diagnostic and prognostic markers for endocrine tumors. Dr. Kebebew is a Fellow of the American College of Surgeons, an internationally recognized expert in endocrine surgery, and has performed more than 3,000 operations on the adrenal, pancreas, parathyroid and thyroid.

Name Position
Bruna Babic M.D. Clinical Fellow
Myriem Boufraqech Ph.D. Postdoctoral Fellow (Visiting)
Mustapha El Lakis M.D. Clinical Fellow
Sudheer Kumar Gara Ph.D. Postdoctoral Fellow (Visiting)
Cristiane Gomes Lima M.D. Guest Researcher
Patience C. Green M.D. Clinical Fellow
Bharatkumar Joshi Clinical Collaborator
Xavier Keutgen M.D. Clinical Fellow
Shweta Kotian Ph.D. Postdoctoral Fellow (CRTA)
Suresh M. Kumar, Ph.D. Staff Scientist
Yi Liu-Chittenden Ph.D. Postdoctoral Fellow (CRTA)
Naris Nilubol, M.D., F.A.C.S. Staff Clinician
Pavel Nockel M.D. Clinical Fellow
Aida Orois Anon Guest Researcher
Dhaval T. Patel, M.D. Staff Clinician
Shashi Ravindran Nurse Practitioner
Jasmine Shell M.D. Clinical Fellow
Shyni Simon CRNP-BC Nurse Practitioner
Amit Tirosh Ph.D. Postdoctoral Fellow (Visiting)
Sophie Wang, M.S. Research Biologist
Douglas S. Wiseman M.D. Clinical Fellow