Edward W. Cowen, M.D., M.H.Sc.
Edward W. Cowen, M.D., M.H.Sc.
Senior Clinician
Head, Dermatology Consultation Service

Center for Cancer Research
National Cancer Institute

Building 10, Room 12N238
Bethesda, MD 20892-1908
301-496-4299

Dr. Cowen is an internationally recognized expert in the diagnosis and management of cutaneous graft-versus-host disease (GVHD). He conducted an independent clinical trial of imatinib mesylate for the treatment of the sclerotic form of GVHD (ScGVHD), and was the first to identify total body irradiation as a risk factor for ScGVHD.

As Head of the Dermatology Consultation Service, Dr. Cowen also specializes in the evaluation of rare and challenging dermatologic syndromes and adverse reactions to novel therapeutic agents.

Areas of Expertise
1) Cutaneous graft-versus-host disease 2) Autoinflammatory skin disease 3) Cancer-related genodermatoses 4) Adverse drug reactions 5) Primary immunodeficiency

Dermatology Consultation Service Dr. Cowen oversees the Dermatology Consultation Service at the NIH Clinical Center. Patients with a variety of rare diseases with cutaneous manifestations are evaluated. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are evaluated and treated. Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country receive training on the Dermatology consult service. 'Grand Rounds at the NIH', an ongoing feature published in the Journal of the American Academy of Dermatology, highlights interesting cases evaluated by the Dermatology consultation service. Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (NCI #04-C-0281) and Principal Investigator of a therapeutic study of anakinra for pustular skin disease(NCI #13-C-0071).

Selected Publications
  1. Hymes SR, Alousi AM, Cowen EW.
    J. Am. Acad. Dermatol.. 66: 515.e1-18; quiz 533-4, 2012. [ Journal Article ]
  2. Martires KJ, Baird K, Steinberg SM, Grkovic L, Joe GO, Williams KM, Mitchell SA, Datiles M, Hakim FT, Pavletic SZ, Cowen EW.
    Blood. 118: 4250-7, 2011. [ Journal Article ]
  3. Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS, Turner ML, Fox LP.
    J. Am. Acad. Dermatol.. 62: 31-7, 2010. [ Journal Article ]
  4. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R.
    N. Engl. J. Med.. 360: 2426-37, 2009. [ Journal Article ]
  5. Pavletic SZ, Martin P, Lee SJ, Mitchell S, Jacobsohn D, Cowen EW, Turner ML, Akpek G, Gilman A, McDonald G, Schubert M, Berger A, Bross P, Chien JW, Couriel D, Dunn JP, Fall-Dickson J, Farrell A, Flowers ME, Greinix H, Hirschfeld S, Gerber L, Kim S, Knobler R, Lachenbruch PA, Miller FW, Mittleman B, Papadopoulos E, Parsons SK, Przepiorka D, Robinson M, Ward M, Reeve B, Rider LG, Shulman H, Schultz KR, Weisdorf D, Vogelsang GB, Response Criteria Working Group .
    Biol Blood Marrow Transplant. 12: 252-66, 2006. [ Journal Article ]

Dr. Cowen received his B.S. in biology and society from Cornell University and his M.D. from the Pennsylvania State University College of Medicine. He then went on to receive specialty training in dermatology and serve as chief resident at the University of Rochester. Dr. Cowen completed a clinical research fellowship in the Dermatology Branch and the Master's program in clinical research from Duke University before joining the Senior Staff in 2004. Since 2009, Dr. Cowen has served as Head of the Dermatology Consultation Service.

Name Position
Olanda M. Hathaway CRNP Nurse Practitioner
Haley Bharat Naik M.D. Clinical Fellow
Sharon Osgood R.N. Clinical Research Nurse
Dominique Pichard M.D. Clinical Fellow

Summary

Dr. Cowen is an internationally recognized expert in the diagnosis and management of cutaneous graft-versus-host disease (GVHD). He conducted an independent clinical trial of imatinib mesylate for the treatment of the sclerotic form of GVHD (ScGVHD), and was the first to identify total body irradiation as a risk factor for ScGVHD.

As Head of the Dermatology Consultation Service, Dr. Cowen also specializes in the evaluation of rare and challenging dermatologic syndromes and adverse reactions to novel therapeutic agents.

Areas of Expertise
1) Cutaneous graft-versus-host disease 2) Autoinflammatory skin disease 3) Cancer-related genodermatoses 4) Adverse drug reactions 5) Primary immunodeficiency

Research

Dermatology Consultation Service Dr. Cowen oversees the Dermatology Consultation Service at the NIH Clinical Center. Patients with a variety of rare diseases with cutaneous manifestations are evaluated. In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are evaluated and treated. Dermatology Branch clinical fellows, fellows from other NIH Institutes, and visiting dermatology residents from around the country receive training on the Dermatology consult service. 'Grand Rounds at the NIH', an ongoing feature published in the Journal of the American Academy of Dermatology, highlights interesting cases evaluated by the Dermatology consultation service. Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (NCI #04-C-0281) and Principal Investigator of a therapeutic study of anakinra for pustular skin disease(NCI #13-C-0071).

Publications

Selected Publications
  1. Hymes SR, Alousi AM, Cowen EW.
    J. Am. Acad. Dermatol.. 66: 515.e1-18; quiz 533-4, 2012. [ Journal Article ]
  2. Martires KJ, Baird K, Steinberg SM, Grkovic L, Joe GO, Williams KM, Mitchell SA, Datiles M, Hakim FT, Pavletic SZ, Cowen EW.
    Blood. 118: 4250-7, 2011. [ Journal Article ]
  3. Cowen EW, Nguyen JC, Miller DD, McShane D, Arron ST, Prose NS, Turner ML, Fox LP.
    J. Am. Acad. Dermatol.. 62: 31-7, 2010. [ Journal Article ]
  4. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R.
    N. Engl. J. Med.. 360: 2426-37, 2009. [ Journal Article ]
  5. Pavletic SZ, Martin P, Lee SJ, Mitchell S, Jacobsohn D, Cowen EW, Turner ML, Akpek G, Gilman A, McDonald G, Schubert M, Berger A, Bross P, Chien JW, Couriel D, Dunn JP, Fall-Dickson J, Farrell A, Flowers ME, Greinix H, Hirschfeld S, Gerber L, Kim S, Knobler R, Lachenbruch PA, Miller FW, Mittleman B, Papadopoulos E, Parsons SK, Przepiorka D, Robinson M, Ward M, Reeve B, Rider LG, Shulman H, Schultz KR, Weisdorf D, Vogelsang GB, Response Criteria Working Group .
    Biol Blood Marrow Transplant. 12: 252-66, 2006. [ Journal Article ]

Biography

Dr. Cowen received his B.S. in biology and society from Cornell University and his M.D. from the Pennsylvania State University College of Medicine. He then went on to receive specialty training in dermatology and serve as chief resident at the University of Rochester. Dr. Cowen completed a clinical research fellowship in the Dermatology Branch and the Master's program in clinical research from Duke University before joining the Senior Staff in 2004. Since 2009, Dr. Cowen has served as Head of the Dermatology Consultation Service.

Team

Name Position
Olanda M. Hathaway CRNP Nurse Practitioner
Haley Bharat Naik M.D. Clinical Fellow
Sharon Osgood R.N. Clinical Research Nurse
Dominique Pichard M.D. Clinical Fellow