Dennis D. Hickstein, M.D.
Dennis D. Hickstein, M.D.
Senior Investigator
Head, Molecular Oncology and Gene Transfer Section

Center for Cancer Research
National Cancer Institute

Building 10 - Hatfield CRC, Room 3-3142
Bethesda, MD 20892-1203
301-594-1718

Dr. Hickstein’s laboratory is developing new approaches to the treatment of the primary immunodeficiency diseases GATA2 deficiency, DOCK8 deficiency, and leukocyte adhesion deficiency type 1 (LAD-1). The current approach uses allogeneic hematopoietic stem cell transplant and autologous hematopoietic stem cell gene therapy. Studies are carried out in animal models of disease and in human clinical trials.

Areas of Expertise
1) bone marrow transplant 2) primary immunodeficiency diseases 3) gene therapy 4) zebrafish

Molecular Oncology and Gene Transfer

The research in our laboratory involves two areas of investigations. The first area of study focuses on the correction of the disease phenotype in three genetic immunodeficiency diseases-leukocyte adhesion deficiency type 1, GATA2 deficiency, and DOCK8 deficiency-using two approaches: allogeneic hematopoietic stem cell transplantation and gene transfer into hematopoietic stem cells. These studies are designed to achieve long-term correction of hematopoietic stem cells. In the second area of study, we are developing zebrafish models of human blood diseases, particularly a zebrafish model of GATA2 deficiency.

Scientific Focus Areas:
Cancer Biology, Genetics and Genomics, Stem Cell Biology
Selected Key Publications
  1. Jennifer Cuellar-Rodriguez, M.D., Alexandra F. Freeman, M.D., Jennifer Grossman, M.D., Helen Su, M.D., Ph.D., Mark Parta, M.D., Heardley Murdock, B.S., Nirali Shah, M.D., Catherine Bollard, M.D., Heidi Kong, M.D., Niki Moutsopoulos, D.V.M., Kelly Stone, M.D., Ph.D., Juan Gea-Banacloche, M.D., Steven M. Holland, M.D., and Dennis D. Hickstein, M.D.
    Biol Blood and Marrow Transplantation. [Epub ahead of print, Jan. 27]: 2015. [ Journal Article ]
  2. Jennifer Grossman, Jennifer Cuellar-Rodriguez, Juan Gea-Banacloche, Christa Zerbe, Katherine Calvo, Thomas Hughes, Kristen Cole, Mark Parta, Alexandra Freeman, Steven M. Holland, Dennis D. Hickstein
    Biol Blood and Marrow Transplantation. 20(12): 1940-1948, 2014. [ Journal Article ]
  3. Heather R. Shive, Robert R. West, Lisa J. Embree, Champa D. Golden, and Dennis D. Hickstein
    PLOS One. 9(1): e87177, 2014. [ Journal Article ]
  4. Cuellar-Rodriguez J, Gea-Banacloche J, Freeman AF, Hsu AP, Zerbe CS, Calvo KR, Wilder J, Kurlander R, Olivier KN, Holland SM, Hickstein DD.
    Blood. 118: 3715-20, 2011. [ Journal Article ]
  5. West RR, Hsu AP, Holland SM, Cuellar-Rodriguez J, Hickstein DD.
    Haematologica. 99(2): 276-81, 2014. [ Journal Article ]

Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.

Name Position
Thomas R. Bauer Jr., Ph.D. Staff Scientist
Lisa Embree Research Biologist
Heather Hunt D.V.M. Special Volunteer
Jeanelle Spencer Ph.D. Postdoctoral Fellow (CRTA)
Laura Tuschong Research Biologist
Robert West Ph.D. Research Biologist

Summary

Dr. Hickstein’s laboratory is developing new approaches to the treatment of the primary immunodeficiency diseases GATA2 deficiency, DOCK8 deficiency, and leukocyte adhesion deficiency type 1 (LAD-1). The current approach uses allogeneic hematopoietic stem cell transplant and autologous hematopoietic stem cell gene therapy. Studies are carried out in animal models of disease and in human clinical trials.

Areas of Expertise
1) bone marrow transplant 2) primary immunodeficiency diseases 3) gene therapy 4) zebrafish

Clinical Trials

Research

Molecular Oncology and Gene Transfer

The research in our laboratory involves two areas of investigations. The first area of study focuses on the correction of the disease phenotype in three genetic immunodeficiency diseases-leukocyte adhesion deficiency type 1, GATA2 deficiency, and DOCK8 deficiency-using two approaches: allogeneic hematopoietic stem cell transplantation and gene transfer into hematopoietic stem cells. These studies are designed to achieve long-term correction of hematopoietic stem cells. In the second area of study, we are developing zebrafish models of human blood diseases, particularly a zebrafish model of GATA2 deficiency.

Scientific Focus Areas:
Cancer Biology, Genetics and Genomics, Stem Cell Biology

Publications

Selected Key Publications
  1. Jennifer Cuellar-Rodriguez, M.D., Alexandra F. Freeman, M.D., Jennifer Grossman, M.D., Helen Su, M.D., Ph.D., Mark Parta, M.D., Heardley Murdock, B.S., Nirali Shah, M.D., Catherine Bollard, M.D., Heidi Kong, M.D., Niki Moutsopoulos, D.V.M., Kelly Stone, M.D., Ph.D., Juan Gea-Banacloche, M.D., Steven M. Holland, M.D., and Dennis D. Hickstein, M.D.
    Biol Blood and Marrow Transplantation. [Epub ahead of print, Jan. 27]: 2015. [ Journal Article ]
  2. Jennifer Grossman, Jennifer Cuellar-Rodriguez, Juan Gea-Banacloche, Christa Zerbe, Katherine Calvo, Thomas Hughes, Kristen Cole, Mark Parta, Alexandra Freeman, Steven M. Holland, Dennis D. Hickstein
    Biol Blood and Marrow Transplantation. 20(12): 1940-1948, 2014. [ Journal Article ]
  3. Heather R. Shive, Robert R. West, Lisa J. Embree, Champa D. Golden, and Dennis D. Hickstein
    PLOS One. 9(1): e87177, 2014. [ Journal Article ]
  4. Cuellar-Rodriguez J, Gea-Banacloche J, Freeman AF, Hsu AP, Zerbe CS, Calvo KR, Wilder J, Kurlander R, Olivier KN, Holland SM, Hickstein DD.
    Blood. 118: 3715-20, 2011. [ Journal Article ]
  5. West RR, Hsu AP, Holland SM, Cuellar-Rodriguez J, Hickstein DD.
    Haematologica. 99(2): 276-81, 2014. [ Journal Article ]

Biography

Dr. Hickstein trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.

Team

Name Position
Thomas R. Bauer Jr., Ph.D. Staff Scientist
Lisa Embree Research Biologist
Heather Hunt D.V.M. Special Volunteer
Jeanelle Spencer Ph.D. Postdoctoral Fellow (CRTA)
Laura Tuschong Research Biologist
Robert West Ph.D. Research Biologist