Connie L. Sommers, Ph.D.
Connie L. Sommers, Ph.D.
Staff Scientist

Our research focuses on deciphering the role of LAT in T cell development and T cell function using transgenic mouse models. In particular, a knock-in mutant of LAT (LATY136F) has revealed an important role for LAT in immune homeostasis since these knock-in mice have a severe lymphoproliferative disease. Our research also investigates the roles of other T cell signal transduction intermediates in the development and function of LATY136F and normal T cells. In addition we have recently been investigating the role of microRNAs in lymphoproliferative disease.

Areas of Expertise
transgenic mouse models, T cell

Contact Info

Connie L. Sommers, Ph.D.
Center for Cancer Research
National Cancer Institute
Bldg. 37, Rm. 2066
Bethesda, MD 20892-4256
301-496-8910
sommersc@helix.nih.gov

Our research focuses on deciphering the role of LAT in T cell development and T cell function using transgenic mouse models. In particular, a knock-in mutant of LAT (LATY136F) has revealed an important role for LAT in immune homeostasis since these knock-in mice have a severe lymphoproliferative disease. Our research also investigates the roles of other T cell signal transduction intermediates in the development and function of LATY136F and normal T cells. In addition we have recently been investigating the role of microRNAs in lymphoproliferative disease.

Selected Publications
  1. Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.
    J. Immunol.. 190: 147-58, 2013. [ Journal Article ]
  2. Schmidt AM, Zou T, Joshi RP, Leichner TM, Pimentel MA, Sommers CL, Kambayashi T.
    Sci Signal. 6: ra101, 2013. [ Journal Article ]
  3. Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.
    PLoS ONE. 8: e66709, 2013. [ Journal Article ]
  4. Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
    Sci Signal. 6: ra99, 2013. [ Journal Article ]
  5. Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.
    Mol. Cell. Biol.. 32: 2748-59, 2012. [ Journal Article ]

Dr. Sommers received her Ph.D. degree from Georgetown University in 1993. She was the first to describe vimentin expression in breast cancer cells and described epithelial-to-mesenchymal transition in breast cancer. During her post-doctoral studies in Dr. Paul Love's laboratory in NICHD, she studied the role of tyrosine kinases in thymocyte development and developed expertise in generating transgenic and knockout mouse models (1994-1999). Since 1999, Dr. Sommers has been a Staff Scientist in Dr. Lawrence Samelson's lab with expertise in using mouse models to study T cell signaling pathways and lymphoproliferative disease.

Research

Our research focuses on deciphering the role of LAT in T cell development and T cell function using transgenic mouse models. In particular, a knock-in mutant of LAT (LATY136F) has revealed an important role for LAT in immune homeostasis since these knock-in mice have a severe lymphoproliferative disease. Our research also investigates the roles of other T cell signal transduction intermediates in the development and function of LATY136F and normal T cells. In addition we have recently been investigating the role of microRNAs in lymphoproliferative disease.

Publications

Selected Publications
  1. Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.
    J. Immunol.. 190: 147-58, 2013. [ Journal Article ]
  2. Schmidt AM, Zou T, Joshi RP, Leichner TM, Pimentel MA, Sommers CL, Kambayashi T.
    Sci Signal. 6: ra101, 2013. [ Journal Article ]
  3. Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.
    PLoS ONE. 8: e66709, 2013. [ Journal Article ]
  4. Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.
    Sci Signal. 6: ra99, 2013. [ Journal Article ]
  5. Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.
    Mol. Cell. Biol.. 32: 2748-59, 2012. [ Journal Article ]

Biography

Dr. Sommers received her Ph.D. degree from Georgetown University in 1993. She was the first to describe vimentin expression in breast cancer cells and described epithelial-to-mesenchymal transition in breast cancer. During her post-doctoral studies in Dr. Paul Love's laboratory in NICHD, she studied the role of tyrosine kinases in thymocyte development and developed expertise in generating transgenic and knockout mouse models (1994-1999). Since 1999, Dr. Sommers has been a Staff Scientist in Dr. Lawrence Samelson's lab with expertise in using mouse models to study T cell signaling pathways and lymphoproliferative disease.