Features

Through the High-Tech Looking Glass

Science begins with observation; scientists have made telescopes to examine things farther away than the eye can see and microscopes to examine things invisible to human vision. Since Robert Hooke in the 17th century used the first microscope to document the existence of living cells, advances in cell biology have been tied to ever more innovative tools for visualizing and analyzing the microscopic world. CCR scientists continue to creatively expand the boundaries of observation to answer longstanding and diverse questions about the inner workings of cells. Read more...

Viral Activity

In the last four decades, HIV has gone from being an unknown killer to the cause of a manageable chronic disease. Stephen Hughes, Ph.D., Chief of CCR’s Retroviral Replication Laboratory, began his study of retroviruses before HIV was identified, but quickly made the virus the main focus of his research career. Hughes is internationally recognized for his work on two of the three essential enzymes in the HIV life cycle: reverse transcriptase (RT) and integrase (IN). His work has shed light on the emergence of drug resistance and, more recently, the nature of reservoirs of HIV that persist despite combination antiretroviral therapy. He has also used engineered host proteins that redirect HIV integration as tools for understanding eukaryotic chromatin organization. Read more...

Vaccines 2.0

In 1974, Jay A. Berzofsky, M.D., Ph.D., now Chief of CCR’s Vaccine Branch, came to NIH to study protein folding. His curious mind and collaborative spirit quickly led him into the intertwined fields of immunology and vaccine development. With close to 500 publications to his name, Berzofsky has pioneered the characterization of B- and T-cell epitopes and their modification to make vaccines directed against cancer and chronic infectious diseases. He has also characterized and taken advantage of the cellular and molecular regulators of immune responses in order to enhance tumor immunity and vaccine efficacy. In the last several years, he has translated many of these strategies into promising clinical trials. From the microcosm of his laboratory, he brings the same spirit of cross-fertilizing, bench-to-bedside research to leading the Vaccine Branch as a whole. Read more...

In The Clinic

Radiation Therapy in the Modern World

Deborah Citrin, M.D., Senior Investigator in CCR’s Radiation Oncology Branch, came to the NIH in 2001 as a radiation oncology resident after completing her medical training at Duke University. Read more...

Finding the Right Care

Trained as a registered nurse and with a doctoral degree in public health, Jane D. is no stranger to the U.S. health care system. But, when she found herself facing a diagnosis of anal cancer in 2013, she felt adrift. Read more...

Commentary

A Surgeon's View of Prostate Cancer

Robert Reiter, M.D., M.B.A., is a Professor of Urology and Molecular Biology, Director of the Prostate Cancer Treatment and Research Program, and Director of Urologic Research at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Read more...

Editorial

Synergies in Research

In 1981, the NCI intramural program enrolled its first patient with AIDS. Given our expertise in epidemiology, cancer, retroviruses, cell biology, immunology, and drug development, our responsibility in the face of this public health crisis seemed obvious. Read more...

News

A Brake for Cancer

MIG6 suppresses tumor initiation and progression driven by mutant EGFR. Read more...

The Power of Families

Genomic analysis of a family with thyroid cancer identifies HABP2 as a tumor suppressor gene. Read more...

Shaping the Future of Cancer Research

CCR supports several programs to foster the next generation of biomedical scientists. Read more...

Always on the Move

A static model of thyroid hormone receptor function is revised. Read more...

Staff News at CCR

Staff announcements at CCR. Read more...

Recent CCR Awards

View the most recent CCR Awards. Read more...

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