Colm S. O'Huigin, Ph.D.
Colm S. O'Huigin, Ph.D.
Staff Scientist (Contr)
Head, Genetic Core Facility

Center for Cancer Research
National Cancer Institute

Building 560, Room 21-28
Frederick, MD 21702-1201
301-846-1717

A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity.

Areas of Expertise
Immunity, computation biology, experimental biology

A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity. To what extent are rapidly evolving pathogens (HIV, HCV) shaped to escape host immunity? Given the disparity of mutation rates compared with their host, can pathogens or commensals shape host immunity?

Selected Publications
  1. Rizvi SM, Salam N, Geng J, Qi Y, Bream JH, Duggal P, Hussain SK, Martinson J, Wolinsky SM, Carrington M, Raghavan M.
    J. Immunol.. 192: 4967-76, 2014. [ Journal Article ]
  2. Dean M, Bendfeldt G, Lou H, Giron V, Garrido C, Valverde P, Barnoya M, Castellanos M, Jiménez-Morales S, Luna-Fineman S.
    Cancer Lett.. 351: 59-63, 2014. [ Journal Article ]
  3. Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, Gao X, Burke PS, Taylor CJ, Rogich J, Wolinsky S, Bream JH, Duggal P, Hussain S, Martinson J, Weintrob A, Kirk GD, Fellay J, Buchbinder SP, Goedert JJ, Deeks SG, Pereyra F, Trowsdale J, Lichterfeld M, Telenti A, Walker BD, Allen RL, Carrington M, Yu XG.
    PLoS Genet.. 10: e1004196, 2014. [ Journal Article ]
  4. Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck H.
    Nat. Med.. 19: 930-3, 2013. [ Journal Article ]
  5. McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay J.
    PLoS Pathog.. 9: e1003515, 2013. [ Journal Article ]

Dr. O'Huigin heads the CIP Genetic Core Facility. His training in both quantitative and molecular genetics was at the Genetics Dept. of Trinity College, Dublin. He learnt the techniques of molecular evolutionary analysis as a postdoctoral fellow with Wen-Hsiung Li at the Center for Population and Demographic Genetics in Houston Texas. As an EMBO fellow he worked at the Max-Planck Institute in Tuebingen, Germany with Jan Klein where later he headed a group working on the origins and genetic characteristics of the major histocompatability complex, on organogenesis and on speciation.

Name Position
Hong Lou Ph.D. Research Fellow (Contr)
Ying Qi Senior Computational Scientist (Contr)

Summary

A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity.

Areas of Expertise
Immunity, computation biology, experimental biology

Research

A background in both computational and in experimental biology, leads naturally to an interest in research that interfaces both approaches. In the areas of inflammation and cancer unravelling the complex patterns of change and regulation of molecules of adaptive (MHC, KIR) and innate (Trim5, IL28B) immunity have provided both bioinformatic and experimental challenges that are being met using comparative sequence analysis and inference. Research interest is also turning to the selective forces associated with immunity. To what extent are rapidly evolving pathogens (HIV, HCV) shaped to escape host immunity? Given the disparity of mutation rates compared with their host, can pathogens or commensals shape host immunity?

Publications

Selected Publications
  1. Rizvi SM, Salam N, Geng J, Qi Y, Bream JH, Duggal P, Hussain SK, Martinson J, Wolinsky SM, Carrington M, Raghavan M.
    J. Immunol.. 192: 4967-76, 2014. [ Journal Article ]
  2. Dean M, Bendfeldt G, Lou H, Giron V, Garrido C, Valverde P, Barnoya M, Castellanos M, Jiménez-Morales S, Luna-Fineman S.
    Cancer Lett.. 351: 59-63, 2014. [ Journal Article ]
  3. Bashirova AA, Martin-Gayo E, Jones DC, Qi Y, Apps R, Gao X, Burke PS, Taylor CJ, Rogich J, Wolinsky S, Bream JH, Duggal P, Hussain S, Martinson J, Weintrob A, Kirk GD, Fellay J, Buchbinder SP, Goedert JJ, Deeks SG, Pereyra F, Trowsdale J, Lichterfeld M, Telenti A, Walker BD, Allen RL, Carrington M, Yu XG.
    PLoS Genet.. 10: e1004196, 2014. [ Journal Article ]
  4. Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck H.
    Nat. Med.. 19: 930-3, 2013. [ Journal Article ]
  5. McLaren PJ, Coulonges C, Ripke S, van den Berg L, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, Deeks SG, Delaneau O, De Luca A, Goedert JJ, Haas D, Herbeck JT, Kathiresan S, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, O'Brien SJ, Pereyra F, Plummer FA, Poli G, Qi Y, Rucart P, Sandhu MS, Shea PR, Schuitemaker H, Theodorou I, Vannberg F, Veldink J, Walker BD, Weintrob A, Winkler CA, Wolinsky S, Telenti A, Goldstein DB, de Bakker PI, Zagury JF, Fellay J.
    PLoS Pathog.. 9: e1003515, 2013. [ Journal Article ]

Biography

Dr. O'Huigin heads the CIP Genetic Core Facility. His training in both quantitative and molecular genetics was at the Genetics Dept. of Trinity College, Dublin. He learnt the techniques of molecular evolutionary analysis as a postdoctoral fellow with Wen-Hsiung Li at the Center for Population and Demographic Genetics in Houston Texas. As an EMBO fellow he worked at the Max-Planck Institute in Tuebingen, Germany with Jan Klein where later he headed a group working on the origins and genetic characteristics of the major histocompatability complex, on organogenesis and on speciation.

Team

Name Position
Hong Lou Ph.D. Research Fellow (Contr)
Ying Qi Senior Computational Scientist (Contr)