Christophe  Cataisson, Ph.D.
Christophe Cataisson, Ph.D.
Staff Scientist

Center for Cancer Research
National Cancer Institute

Building 37, Room 4060
Bethesda, MD 20892
301-496-8898

Dr. Cataisson’s research expertise is centered on skin carcinogenesis (cutaneous squamous cell carcinoma) following two-stage chemical carcinogenesis (DMBA-TPA). He also uses primary mouse keratinocytes to define phenotypic changes caused by oncogenic RAS. He uses genetically modified mouse models to study pathways contributing to carcinogenesis (PKC, MyD88, CXCR2, EGFR, MET, MTOR). Using an in vivo grafting model on syngeneic host has allowed Dr. Cataisson to probe the respective contribution of cancer cells and their stroma to tumor formation.

Dr. Cataisson’s integrated research takes advantage of using primary cells transformed by a single hit (oncogenic RAS) and exploring their phenotype in vivo in a relevant context.

Areas of Expertise
skin carcinogenesis, RAS, primary keratinocytes, skin inflammation, MyD88, PKC, grafting, carcinoma, papilloma.

Dr. Cataisson's research expertise is centered on two interrelated areas. He uses mouse models to define pathways contributing to skin inflammation with special emphasis on the chemokine family binding CXCR2. In other studies, he is investigating the role of inflammation in the tumor microenvironment using epidermal squamous carcinoma as a model.

Selected Publications
  1. Garrido C, Santizo VG, Müllers P, Soriano DR, Avila GB, Dean M, Jimenez-Morales S.
    Med. Oncol.. 30: 474, 2013. [ Journal Article ]
  2. Dean M, Lou H.
    Asian J. Androl.. [Epub ahead of print], 2013. [ Journal Article ]
  3. Cataisson C, Pearson AJ, Tsien MZ, Mascia F, Gao JL, Pastore S, Yuspa SH.
    J. Clin. Invest.. 116: 2757-66, 2006. [ Journal Article ]
  4. Cataisson C, Joseloff E, Murillas R, Wang A, Atwell C, Torgerson S, Gerdes M, Subleski J, Gao JL, Murphy PM, Wiltrout RH, Vinson C, Yuspa SH.
    J. Immunol.. 171: 2703-13, 2003. [ Journal Article ]
  5. Jiménez-Morales S, Jiménez-Ruíz JL, Del Río-Navarro BE, Navarro-Olivos E, Escamilla-Guerrero G, Savan R, Dean M, Orozco L.
    Mol. Biol. Rep.. 41: 2109-17, 2014. [ Journal Article ]

Dr. Christophe Cataisson received a MS diploma in cellular biology and physiology from University Blaise Pascal, Clermont-Ferrand, France in 1995. He then moved to University of Jussieu, Paris, France where he received his Ph.D. in December 2000 for his work on the regulation and function of the Parathyroid Hormone related Peptide (PTHrP) gene in human mammary cancer cells. In 2001, he joined the laboratory of Dr. Yuspa as a visiting fellow to receive his post-doctoral training.

Summary

Dr. Cataisson’s research expertise is centered on skin carcinogenesis (cutaneous squamous cell carcinoma) following two-stage chemical carcinogenesis (DMBA-TPA). He also uses primary mouse keratinocytes to define phenotypic changes caused by oncogenic RAS. He uses genetically modified mouse models to study pathways contributing to carcinogenesis (PKC, MyD88, CXCR2, EGFR, MET, MTOR). Using an in vivo grafting model on syngeneic host has allowed Dr. Cataisson to probe the respective contribution of cancer cells and their stroma to tumor formation.

Dr. Cataisson’s integrated research takes advantage of using primary cells transformed by a single hit (oncogenic RAS) and exploring their phenotype in vivo in a relevant context.

Areas of Expertise
skin carcinogenesis, RAS, primary keratinocytes, skin inflammation, MyD88, PKC, grafting, carcinoma, papilloma.

Research

Dr. Cataisson's research expertise is centered on two interrelated areas. He uses mouse models to define pathways contributing to skin inflammation with special emphasis on the chemokine family binding CXCR2. In other studies, he is investigating the role of inflammation in the tumor microenvironment using epidermal squamous carcinoma as a model.

Publications

Selected Publications
  1. Garrido C, Santizo VG, Müllers P, Soriano DR, Avila GB, Dean M, Jimenez-Morales S.
    Med. Oncol.. 30: 474, 2013. [ Journal Article ]
  2. Dean M, Lou H.
    Asian J. Androl.. [Epub ahead of print], 2013. [ Journal Article ]
  3. Cataisson C, Pearson AJ, Tsien MZ, Mascia F, Gao JL, Pastore S, Yuspa SH.
    J. Clin. Invest.. 116: 2757-66, 2006. [ Journal Article ]
  4. Cataisson C, Joseloff E, Murillas R, Wang A, Atwell C, Torgerson S, Gerdes M, Subleski J, Gao JL, Murphy PM, Wiltrout RH, Vinson C, Yuspa SH.
    J. Immunol.. 171: 2703-13, 2003. [ Journal Article ]
  5. Jiménez-Morales S, Jiménez-Ruíz JL, Del Río-Navarro BE, Navarro-Olivos E, Escamilla-Guerrero G, Savan R, Dean M, Orozco L.
    Mol. Biol. Rep.. 41: 2109-17, 2014. [ Journal Article ]

Biography

Dr. Christophe Cataisson received a MS diploma in cellular biology and physiology from University Blaise Pascal, Clermont-Ferrand, France in 1995. He then moved to University of Jussieu, Paris, France where he received his Ph.D. in December 2000 for his work on the regulation and function of the Parathyroid Hormone related Peptide (PTHrP) gene in human mammary cancer cells. In 2001, he joined the laboratory of Dr. Yuspa as a visiting fellow to receive his post-doctoral training.