The Center for Immuno-Oncology (CIO), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) invites applications for a Staff Scientist position to lead the laboratory’s analysis of tumor immune micro-environment (TIME) in clinical samples of patients treated with immune-therapeutic agents. This is an outstanding career opportunity in the NCI for a scientist who wishes to study the complex interaction between the tumor and immune cells and to find the key players for a successful therapeutic anti-tumor response using newly developed agents that target the immune system. The laboratory is using state-of-the-art technologies for analysis of TIME including multiplexed multispectral imaging, single cell RNA-Seq and digital spatial transcriptomics. The staff scientist will oversee assays including scRNA-Seq, TIL analysis and digital spatial transcriptomics along with the TIME staff. The staff scientist will use these tools to understand and characterize the tumor-immune cells interaction and study its evolution in primary and metastatic tumor and during treatment. The staff scientist will support the clinical team by defining biomarkers for patient selection/stratification, studying mechanism of action, etc. This is a key leadership position in the James Gulley laboratory, located on the main NIH campus in Bethesda, Maryland and consisting of highly collaborative researchers.
For more information, see Center for Immuno-Oncology.
Who We Are
The Center for Cancer Research (CCR) is the intramural research component of the NCI. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, provides extensive opportunities for collaboration, and allows scientists and clinicians to undertake high-risk, high- impact laboratory and clinically based investigations. Investigators are supported by a wide array of intellectual, technological and research resources including, animal facilities and dedicated, high-quality technology cores in areas such as imaging/microscopy, chemistry/purification, mass spectrometry, flow cytometry, genomics/DNA sequencing, transgenics and knockout mice, arrays/molecular profiling, and human genetics/bioinformatics. For an overview of CCR, please visit Center for Cancer Research.
The successful candidate must possess a Ph.D. degree in immunology, molecular biology, or related field and at least 3 years of post-doctoral research experience, and a strong publication record in cancer biology with an emphasis on immunology, oncology/immuno-oncology, transcriptomic analysis or similar.
Full Federal benefits including leave, health insurance, life insurance, long-term care insurance, retirement, and a Thrift Savings Plan (401k equivalent) will be provided. Candidates may be U.S. citizens, U.S. permanent residents, or eligible for a visa that will enable work in the United States. This position is subject to a background investigation.
Selection for this position will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities. NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis. The NIH is dedicated to building a diverse community in its training and employment programs. Salary and benefits are commensurate with research experience and accomplishments.
Qualifications and Job Details
Required and Preferred Skills
Must have a background in immunology, molecular biology, or a related field and a strong publication record in cancer biology with an emphasis on immunology, oncology/immuno-oncology, transcriptomic analysis or similar.
Background in the study of the complex interaction between the tumor and immune cells using newly developed agents that target the immune system. Immunology, molecular biology, or related field. Use of multispectral imaging, single cell RNA-Seq and digital spatial transcriptomics.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.
How To Apply
Interested individuals should send a curriculum vitae and 3 letters of reference to:
James Gulley, M.D., Ph.D.
Center for Immuno-Oncology, CCR, NCI
Applications will be accepted through March 17 – April 15, 2023.