Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Staff Scientist - Immunology, Cancer Research, Immunotherapy

Job Description:

Position is with:

The Experimental Transplantation and Immunotherapy Branch (ETIB) is dedicated to coordinated efforts in basic, preclinical and clinical investigations in the areas of immunology, hematopoiesis, and hematopoietic stem cell transplantation. The goal is to generate information from basic and preclinical investigations leading to the development of new, curative hemapoietic stem cell transplant-based therapies for cancer. Information from new treatment protocols (including novel endpoints generated in the course of basic/preclinical research) is used to generate new questions and studies in the basic and preclinical research efforts. The branch emphasizes excellence in these endeavors and acts to maximize strengths present in the community at large by vigorous intramural interactions and collaborations. ETIB is a dynamic community of laboratory-based and clinical researchers with constant interactions and a commitment to excellence in the care of patients and in the quality and innovation of research as well as a commitment to optimizing the translational research environment for branch members.

This is a Staff Scientist 1 position to support the new ETIB Mass Spectrometry and Epitope Discovery Facility within the ETIB, NCI. We established an ETIB Mass Spectrometry (MS) Facility in July 2020 to make mass spec available across the ETIB for multiple projects, including epitope discovery. Unique patient material exists in ETIB to promote the identification of T cell epitopes, specifically T cell populations arising in the post-transplant period which mediate tumor regression or resolution of viral infections (either associated with the patient’s neoplasm or as an infectious complication of transplant). The new MS facility in ETIB has two tandem mass spectrometers (UPLC-QTof (MS) and GC-QqQ (MS)) that can be used to support the immunotherapy research.  The QTof MS and proteomics software was recently purchased specifically for protein/peptide analysis and is currently being installed/setup for peptide epitope discovery research. The scientist's primary task will be to lead laboratory research efforts as it relates to epitope discovery, biological and chemical characterizations, and subsequent development of treatments (immunotherapy) for targeted cancer and viral infections. This work is necessary for the growth of our Institute, which is charged with the study of basic biomedical research methods. The scientist will prepare reports and manuscripts based on research findings and will present at scientific meetings as necessary.

This is a great opportunity for candidates who are interested in cancer biology and want to grow their research career by working in our program with outstanding support of other established laboratories and core facilities in the National Cancer Institute.

The scientist will be tasked with independent research projects that support and/or further the scope of our laboratory goals as determined by the PI, whom the scientist will regularly report to with continuous updates. The scientist will be responsible for overseeing daily operations and coordination of projects in close conjunction with all laboratory personnel. The scientist will participate in teaching laboratory methods to first-time post-docs, research fellows, and students.  This is a leadership role within the daily operations of the lab and the scientist needs to be highly proficient as a “go-to” technical resource.The scientist will work closely with a full-time research biologist both in collaboration of research projects and in lab-critical administrative tasks of IRB-approval, animal protocols, budget, etc.  

We emphasize a team-based approach.  Individuals with self-motivation, excellent communication skills, patience to teach and a willingness to collaborate will be most successful in this environment.  The scientist needs to be adaptable to our ongoing scientific evolution, so independent learning is a critical skill for success.

Qualifications and Job Details:

  • Degree Required:
    • Ph.D. or equivalent
    • M.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Government Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Salary: Commensurate with experience

REQUIRED SKILLS: Qualified candidates should have a Ph.D. in a biological science area or the equivalent background (M.D., M.B.B.S., etc.) with five or more years of post-doctoral experience. A background and working knowledge in immunotherapy/cancer research is required as well as familiarity with using cancer immunotherapy techniques, which will benefit our primary mission.

PREFERRED SKILLS: Previous research experience in immunology, cancer or stem cell biology, and/or peptide epitope discovery would be highly advantageous.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

  • CV/Resume
  • Statement of Research Goals
  • Three References

Contact Name: Betty Garcia

Contact Email:

For questions contact: Betty Garcia,

HHS, NIH, and NCI are Equal Opportunity Employers