Staff Scientist - DNA Repair, Anti-cancer Drugs

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

A Staff Scientist position is available in the laboratory of Dr. Yuichi Machida in the Developmental Therapeutics Branch (DTB), NCI-NIH to study DNA repair mechanisms and their effect on anti-cancer drug sensitivity. Dr. Machida’s research focuses on proteases involved in the repair of DNA-Protein Crosslink (DPC) damage. The successful candidate will study proteolytic DPC repair mechanisms using molecular and cellular biology techniques as well as mouse genetics. To learn more about the research in the Machida lab, please visit:

The Developmental Therapeutics Branch (DTB) offers a collaborative and highly interactive research environment. Opportunities are available to interact with the members of the multidisciplinary research community in the DTB consisting of basic scientists, bioinformaticians and clinical scientists. We are committed to creating an inclusive research environment and supporting successful research careers of all trainees.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Government Position (Salary commensurate with experience)
Work Schedule
Full-time (In-Person)
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Qualified candidates must have a minimum of 4 years of postdoctoral training in a field deemed relevant by the program.

Preferred Skills

Candidates with a background in DNA repair or experience in the following areas are encouraged to apply:

  • Structural biology
  • Mouse studies
  • Genomics
  • Proteomics
  • CRISPR screening
  • Genome editing
  • Single-molecule studies
  • Assay development

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
  • Cover Letter
  • Summary of Research Experience
Contact Information
Contact Name
Yuichi Machida
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.