Staff Scientist - Clinical Genomics, Next-gen sequencing

Staff Name: 
Kenneth Aldape, M.D.
Laboratory of Pathology
Research Area Keywords: 

Clinical Genomics, Next-generation sequencing

Position Description: 

The Laboratory of Pathology (LP), Center for Cancer Research (CCR) of the National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, is actively recruiting for a Staff Scientist to work in the area of clinical genomics and to participate in our expanding clinical genomic program. In particular, the LP has several NGS-based assays to identify genetic changes in clinical samples derived from cancer patients seen by the intramural program of the NCI. The Scientist will work with pathologists, bioinformaticians, wet lab scientists and support staff in the LP to analyze data and generate clinical pathology reports. This position represents an effort to build on the LP’s growing interest and expertise in both scientific discovery in cancer genomics and clinical application of genomic studies on human cancer specimens.

The future of cancer care is precision medicine. This is an exciting opportunity for an individual with interests in both cancer gene discovery and the application of next-generation sequencing and genome-wide epigenetic profiling approaches in the clinical setting of diagnostic pathology.

The ideal candidate will have experience and expertise in the analysis of alterations in cancer genes, epigenomics, gene expression and/or DNA copy number in human tumor specimens and model systems. Emerging evidence indicates the utility of cancer genomic and epigenomic analysis to be contributory not only to specific therapeutic choices, but also to tumor classification and precision diagnostics. Integration of molecular alterations within the context of clinical cancer diagnostics represents an exciting direction that would be expected of the successful applicant.

The successful candidate will join dynamic diagnostic laboratory and will have array of responsibilities including but not limited to (1) annotation, interpretation and reporting NGS somatic variants in the context of relevant biomedical findings; (2) interpretation of results of tumor classification based on whole genome DNA-methylation profiling; (3) integration of these findings with pathological diagnosis and reporting of clinical significant and actionable findings according to ACMG/AMP/CAP guidelines using clinical laboratory information system. Additional responsibilities include presentation of molecular findings and interpretations at the tumor boards and weekly conferences with physicians involved in the management of cancer patients.

Research interests of the successful applicant may include investigation of the genetic and molecular landscape of a wide range of cancers as well as systematic genome-wide approaches to interrogate the function of cancer genes and the vulnerabilities of tumors. The incumbent will lead the effort that integrates high complexity cancer next generation sequencing (NGS) and whole genome DNA methylation-based tumor profiling into clinically actionable diagnostic reports.

CCR is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences. 

Our scientists can’t do it alone. It takes a skilled, multi-disciplinary team of dedicated staff in research, patient care and administration to improve the lives of cancer patients and answer the most important questions in cancer biology and treatment. Be part of our mission to unlock the mysteries of cancer through research to create the medicines of tomorrow.

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

The successful candidate should have an M.D. or Ph.D. degree and a well-established track record of publications in the area of clinical genomics. The ideal candidate will work closely with academic pathologists to help drive the correlative studies that will be an essential component of integrated genomic analyses. This is an exciting opportunity to join a growing trans-institutional, translational research team that will promote and support collaborations across the basic, translational, and clinical research spectrum as the field of diagnostic pathology navigates through the genomic era. The successful applicant will provide demonstratable leadership implementing cancer genomics into basic and/or translational research and be highly collaborative. Candidates will be evaluated on their educational background, scholarly work, leadership and mentoring activities, and experience. Salary will be commensurate with education and experience. Candidates may be U.S. citizens, U.S. permanent residents, or eligible for a visa that will enable work in the United States.

Additional Information: 

Bethesda, located adjacent to Washington, D.C., is an urban core of Montgomery County, MD. Bethesda is one of the most affluent and highly educated communities in the United States. Living in Bethesda offers residents a suburban feel with a lot of restaurants, coffee shops, and parks. The public schools in Bethesda are highly rated. 

How To Apply: 

Please submit curriculum vitae, contact information for 3 references, and statement of research interests and future plans to: Mr. Adam Collett at Review of applications will begin on or about January 2, 2020 and the position will remain open until filled.

Contact Name: 
Adam Collett
Contact E-mail: 
Contact Phone: 
(240) 858-3295

HHS, NIH, and NCI are Equal Opportunity Employers