Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

Join us!

Staff Scientist - chromatin, atomic force microscopy, centromeres, nucleosomes

Job Description:

Position is with:

The Chromatin Structure and Epigenetic Mechanisms Group is a wet-bench laboratory within the exceptionally integrated research environment of the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research (CCR), National Cancer Institute (NCI). Our lab focuses on chromosome dynamics and epigenetics in normal and human cancer cells. We seek to understand how chromatin is regulated, how chromatin structures evolve, and when misregulated, how chromatin contributes to cancer and aging. We use a broad range of techniques, including chromatin biochemistry, computational modeling, single molecule AFM microscopy, immunofluorescence, genetics, genomics, and standard cell/molecular biology. We are currently investigating how chromatin complexes adopt alternate structural conformation in silico, in vitro, and in vivo, and the functional consequences of mutations within chromatin variants, remodelers, and chaperones upon the cancer epigenome. We have long-standing interdisciplinary collaborations with intramural and extramural groups across the National Institutes of Health (NIH), the United States, and abroad. For more information visit our webpage. CCR is the intramural research component of NCI. CCR’s robust infrastructure and supportive leadership facilitates technological breakthroughs, clinical studies at the NIH Clinical Center, the world’s largest dedicated clinical research complex, and extensive opportunities for collaboration. This allows exceptionally talented scientists and clinicians to undertake high-risk, high-impact laboratory- and clinic-based investigations.

The Center for Cancer Research (CCR) is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences. 

Our scientists can’t do it alone. It takes a skilled, multi-disciplinary team of dedicated staff in research, patient care and administration to improve the lives of cancer patients and answer the most important questions in cancer biology and treatment. Be part of our mission to unlock the mysteries of cancer through research to create the medicines of tomorrow.

Qualifications and Job Details:

  • Degree Required: Ph.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Government Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required
  • Salary: Commensurate with experience


The successful candidate will hold a Ph.D. degree, with an emphasis on biophysics, biochemistry, or molecular biology; have five years of post-doctoral experience; and a robust first-author publication record demonstrating excellence in chromosome biology. Previous published experience in atomic force microscopy and chromatin biology is required. 

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

  • CV/Resume
  • Three References
  • Cover Letter

Contact Name: Yamini Dalal

Contact Email:

For questions contact: Yamini Dalal,

HHS, NIH, and NCI are Equal Opportunity Employers