Staff Scientist - Bioinformatics, computational biology

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

The Cancer and Developmental Biology Laboratory (CDBL), CCR, NCI, NIH, in Frederick, Maryland, is recruiting a Staff Scientist with demonstrated expertise in bioinformatics and computer science. The candidate will work in collaboration with CDBL principal investigator (PI) labs on analysis and integration of bioinformatic and quantitative developmental biology data.

The candidate will be embedded in the CDBL: a diverse, interactive, collaborative, and highly supportive basic science-focused department. The candidate will work with CDBL PI teams in support of their studies. There are currently seven CDBL PIs: Jairaj Acharya, Usha Acharya, Ira Daar, Erin Davies, Mark Lewandoski, Susan Mackem and Terry Yamaguchi. Primary responsibilities will be to consult and provide bioinformatics and computational support for CDBL PI teams using high throughput sequencing and mass spectrometric methods (e.g., bulk and single-cell RNAseq, ChIPseq, ATACseq, HiC, metabolomics, lipidomics, proteomics), to collaborate on projects focused on signaling pathways and organization of gene regulatory networks in developmental systems.  The scientist will also be responsible for supervising and helping to train junior fellows in basic bio-informatic tools to assist in analyses for these projects, which will extend their ability to oversee multiple projects simultaneously.

For additional information about the CDBL, please visit

The staff scientist position is the equivalent to a Senior Research Associate position in academia. A staff scientist is an NIH Full-Time Equivalent (FTE) employee generally appointed to a time-limited, renewable appointment. Staff scientists do not receive independent resources, although they often work independently and have sophisticated skills and knowledge essential to the work of the laboratory.

Salary is commensurate with education and experience.  A full benefits package is available, including retirement, health insurance, life insurance, annual and sick leave, and Thrift Savings Plan (401K equivalent).

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Government Position (Salary commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

A strong background in computational skills is essential, including familiarity with Unix OS; programming languages such as R, Python, Perl; biostatistics; machine learning; algorithms.  Experience in applying genomic data analysis to problems in genetics and physiology and some background in developmental biology are also highly desirable. Analyses may include bulk and single-cell transcriptomics, chromatin structure and epigenetic data, whole genome sequencing and multi-omics data integration. Analyses may use existing bioinformatics pipelines or may require development of new computational approaches.  The candidate will develop computational tools for genomics, transcriptomics, specifically for analysis of single cell gene expression data, ATAC sequencing, epigenomics, and metabolomics data. The candidate is expected to apply machine learning, deep learning, statistical inferences, and bioinformatics methods in analytical approaches, and should be familiar with strategies for genome analysis adapted to a variety of model organisms.  They will be expected to develop and maintain bioinformatics pipelines for various genomics application, develop web-based in-house database interface.

The position requires the ability to work semi-independently on multiple projects and to interact closely with, and be highly responsive to, the CDBL research teams. As a close collaborator and co-author, the staff scientist will be an integral part of the research teams, will meet regularly with the PIs, will make informal presentations in PI lab and CDBL meetings, and participate in the writing of manuscripts.

Applicants should hold a Ph.D. or equivalent doctoral degree, in bioinformatics, computational biology or computer sciences and have a strong record of peer-reviewed publications that provide evidence of their collaborative abilities and expertise.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply
  • CV/Resume
  • Statement of Research Goals
  • References
  • Cover Letter
  • Summary of Research Experience
Additional Application Information

Please email cover letter, curriculum vitae, statement of research goals, summary of research experience and the names and contact information for five references (two collaborators) to: Erin Leatherman, Administrative Officer, NCI-Frederick,  Applications will be accepted until the position is filled.

Contact Information
Contact Name
Erin Leatherman
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.