Center for Cancer Research

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Senior Investigator - Transmission Electron Microscopy; Real-Time Cryo-EM

Job Description:

Position is with:

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Structural Biology Laboratory (SBL) is seeking an internationally leading tenure-eligible scientist to establish an independent research group focused on developing computational methods for transmission electron microscopy (TEM) with a preference for candidates with an interest in innovative approaches to the analysis of real-time cryo-EM and time resolved TEM data.

Taking advantage of the stable resources provided by the NCI Intramural Research Program, the successful candidate will have the opportunity to lead an impactful research program, including methodological development of transmission electron microscopy techniques, computational methods for real-time cryo-EM and in situ liquid cell TEM, and computational methods capable of integrating data from multiple spatiotemporal imaging sources at resolutions ranging from cellular to biomolecular to atomic. The investigator will be appointed as an NIH tenured Senior Investigator, a position which is equivalent to an academic professor.

The NCI is committed to building an exceptional SBL with state-of-art facilities and outstanding faculty that will enable cutting-edge structure determination and analysis to uncover the mechanistic biology of important macromolecular mediators of cancer and other diseases leading to likely targets of therapeutic intervention. This effort is centered on the Frederick campus, which currently houses a wide range of technological assets, including nuclear magnetic resonance, X-ray crystallography (in-house X-ray diffraction facilities and national synchrotron and free electron laser facilities), small angle X-ray scattering (in-house and synchrotron-based), cryo-electron microscopy, computational biology, and a well-equipped biophysics core facility. In addition, high-quality cores dedicated to protein chemistry, mass spectrometry, imaging, microscopy, proteomics, genomics, bioinformatics/biostatistics, and flow cytometry, as well as clinical support at the NIH Clinical Center are available, providing a truly unique research environment. Strengthening of instrumentation for cryo-EM drives this recruitment.

NCI is part of the National Institutes of Health (NIH) in the Department of Health and Human Services, a federal government agency. The CCR is the largest component of the intramural biomedical research effort at NIH and is a major user of the NIH Clinical Research Center, a state-of-the-art research hospital on the Bethesda, Maryland campus. The CCR offers a tremendous depth and breadth of intellectual and technological resources, as well as opportunities for collaboration with investigators both within and outside of the NIH. The research environment is highly conducive to advancing translational research and highly collaborative, emphasizing multidisciplinary and interdisciplinary team science. 

Qualifications and Job Details:

  • Degree Required: Ph.D. or equivalent; M.D. or equivalent
  • Location: Frederick, Maryland
  • Appointment Type: Government Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required
  • Salary: Commensurate with experience


Tenured faculty or industrial scientists of equivalent rank with a demonstrated commitment to computational cryo-EM methods development and a collaborative approach are encouraged to apply. Applicants should should possess excellent communication and leadership skills.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply:

  • CV/Resume
  • Statement of Research Goals
  • One Reference
  • Cover Letter
  • Summary of Research Experience

Additional Application Information:

For more information, contact Lori Holliday, Faculty Recruitment Coordinator at

Contact Name: Lori Holliday

Contact Email:

For questions contact: Lori Holliday,

HHS, NIH, and NCI are Equal Opportunity Employers