Center for Cancer Research

To improve the lives of cancer patients by solving important, challenging and neglected problems in cancer research and patient care.

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Senior Investigator - chromatin pharmacology, DNA replication, genomic instability

Job Description:

Position is with:

The National Cancer Institute (NCI), Center for Cancer Research (CCR), Developmental Therapeutics Branch (DTB) is seeking an outstanding, internationally known scientist to lead an independent research group focused on the cellular responses to replication stress and chromatin alterations and their exploitation in cancer therapy.  

The DTB advances novel therapeutic strategies and conducts clinical trials based on cancer-specific genomic, epigenetic and metabolic alterations, drug design, molecular mechanisms of drug action to achieve precision medicine. The branch integrates both basic and translational science programs. The basic program focuses on cancer-specific genomic and epigenomic alterations, oxidative signaling, molecular pharmacology and drug resistance. The translational clinical program focuses on novel therapeutic agents across a spectrum of diseases and disease mechanisms. Novel therapeutic modalities are selected based on pharmacodynamic and genomic biomarkers and mechanistic hypotheses to assess clinical activity and molecular determinants of response at the early phase of drug development.

The successful candidate will be eligible to be appointed as a tenured NIH Senior Investigator and will lead his/her own individual world-class research program, supported by generous stable resources, including access to a wide range of NCI technology platforms and interdisciplinary collaborations within NCI as well as at NIH and its Clinical Center.

Qualifications and Job Details:

  • Degree Required: Ph.D. or equivalent
  • Location: Bethesda, Maryland
  • Appointment Type: Government Position
  • Work Schedule: Full-time position
  • Citizenship: US Citizenship not required - (ie, permanent resident, visa)
  • Salary: Commensurate with experience


We seek candidates with interest and experience in chromatin pharmacology, chromatin perturbation, DNA replication, DNA repair, replication stress, and/or genomic instability. Applicants should hold a Ph.D., M.D., or equivalent doctoral degree in a relevant discipline and should possess excellent communication and leadership skills.

About the NCI Center for Cancer Research:

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply:

  • CV/Resume
  • Statement of Research Goals
  • Cover Letter

Additional Application Information:

Tenured faculty or industrial scientists of equivalent rank are encouraged to apply. Salary will be commensurate with experience. A full civil service package of benefits (including health insurance, life insurance, and retirement) is available.

Candidates may be U.S. citizens, U.S. permanent residents, or eligible for a visa that will enable work in the United States.

Interested applicants should submit:
A letter of interest in the position, including a career synopsis
A statement of research interests (up to three pages)
A current curriculum vitae and complete bibliography (Please include in your CV a description of your mentoring and outreach activities, especially those involving women and persons from racial/ethnic and other groups that are underrepresented in biomedical research.)

Applications must be submitted to: Initial review of applications will begin approximately 1/18/2021. This position will remain open until filled. Applications will be treated as confidential.

Contact Name: Patrick Miller

Contact Email:

For questions contact: Patrick Miller,

HHS, NIH, and NCI are Equal Opportunity Employers