Research Associate II

Research Area Keywords: 

mouse models, tumor models, preclinical, animal research 

Position Description: 

The Research Associate II is responsible for:

  • Engaging in the validation, characterization, and preclinical evaluation of genetically engineered mouse models for cancer as a critical member of the Center for Advanced Preclinical Research (CAPR) at the Frederick National Laboratory for Cancer Research.  Coordinating and performing a variety of experiments aimed at the evaluation of anticancer therapeutics in genetically engineered mouse models as well as allograft models. Administering drugs by IP, IV or oral gavage routes. Performing complex survival surgeries.  Performing viral and/or cell injections by multiple routes.  Monitoring animal health status.  Collecting body fluids and tissues. Performing tissue culture laboratory work, including maintenance of primary mouse cultures and established cell lines
  • Collecting, preparing, and storing tissue samples Interface regularly with lead scientific staff to organize, coordinate and schedule experimental work
  • Preparing technical reports, summaries, protocols, quantitative analyses, and maintaining appropriate documentation of experiments in Excel and other software.  Assisting CAPR scientists in preparation of data for presentations and reports.  
Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 


  • Possession of a bachelor’s degree from an accredited college or university according to the Council for Higher Education Accreditation (additional qualifying experience may be substituted for the required education); foreign degrees must be evaluated for U.S. equivalency;
  • In addition to the educational requirements, a minimum of five (5) years of related biomedical/research experience;
  • Experience in conducting experiments using mouse models, preferably preclinical drug evaluation in tumor models;
  • Ability to perform a variety of technical and/or surgical procedures on laboratory animals (rodents), maintain experimental data, and train animal care personnel in specific health observations as needed;
  • Ability to keep computer records and maintain data in computer-based applications/databases;
  • Complexity of mouse models and drug evaluation studies will require strong organizational skills as well as very detailed and accurate record keeping;
  • Knowledge of standard operating procedures for animal facilities, and a basic understanding of maintaining laboratory animals is essential;
  • Ability to communicate with project lead researchers in a demanding scientific environment;
  • Must be able to obtain and maintain a security clearance.


  • Basic laboratory skills (DNA, RNA preparation, tissue culture);
  • Experience with mouse models of cancer and cancer therapeutics, as well as ability to maintain cancer cells in culture;
  • Cancer biology experience preferred but not essential;
  • Previous work with viral or chemical tumor induction methods or surgeries on rodents.
Additional Information: 

Hiring for this position will be through Leidos Biomedical Research Inc., a wholly owned subsidiary of Leidos, Inc. Leidos Biomedical is the operations and technical support contractor for the Frederick National Laboratory for Cancer Research, a federal national laboratory.

Contact Name: 
Patti Fitzsimmons
Contact E-mail: 

HHS, NIH, and NCI are Equal Opportunity Employers