Postdoctoral Fellows - RNA biology

Staff Name: 
Eugene Valkov, Ph.D.
RNA Biology Laboratory
Research Area Keywords: 

RNA biology, structural biology, biochemistry, cryoEM

Position Description: 

The Center for Cancer Research (CCR) is working to solve the most pressing problems in the field through basic, translational and clinical cancer research to create the cancer medicines of tomorrow and is dedicated to preparing the next generation of cancer researchers. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

The NCI Center for Cancer Research (CCR) is dedicated to preparing the next generation of cancer researchers and offers a training environment that is second-to-none in quality of science and mentoring by outstanding principal investigators, including nine members of the National Academy of Science and eight members of the National Academy of Medicine. CCR offers fellows access to cutting-edge technologies and cores, a highly collaborative environment, awards and research forums to recognize outstanding post docs, continuous scientific symposia and lectures featuring leading researchers, a strong commitment to translational research, and a vibrant clinical research program housed in the world’s largest dedicated research hospital, the NIH Clinical Center. 

The focus of Dr. Valkov's research group is to understand the mechanisms by which the function of messenger RNA is regulated. We are especially interested in exploring in molecular detail the processes of deadenylation and decapping as well as the connections in the metazoan 5´-to-3´ cytoplasmic degradation pathway. Recently, we have described the biochemical reconstitution of human CCR4-NOT deadenylation complex and uncovered new links between decay factors. The next stage will be to take structural approaches, especially high-resolution cryoEM, in combination with other biophysical techniques toward the study of the human mRNA decay machinery. Significant preliminary data has already been generated for several projects and candidates will join an established research program.

For high-resolution cryoEM, a Talos Arctica equipped with a K3 detector together with a Vitrobot plunger is available on site together with a Talos L120C for screening. Titan Krios microscopes are also locally accessible at dedicated facilities on the NIH campuses in Frederick and Bethesda. For crystallography, there is regular access to synchrotron beamlines at the Argonne National Laboratory. Automated crystallization platforms and automated imagers for crystal detection are available in the neighboring Structural Biophysics Laboratory. In addition, a biophysics core facility contains an array of instruments for biophysical characterization. High-performance computational resources, including a GPU-enabled cluster, are also provided. Further information about the core facilities can be found here:

Number of Positions: 
C.V. Required: 
Number of References Required: 
Experience Required: 

We are looking for enthusiastic, imaginative and dedicated scientists to join our research team working on exciting RNA structural biology projects. Research experience in RNA biology or structural/biophysical techniques will be considered advantageous. Strong work ethic, excellent communication skills and ability to work in a multidisciplinary team are essential. Candidates must have a doctoral degree or expect to receive their degree shortly.

Additional Information: 

More information can be found at The RNA Biology Laboratory is located on the Frederick campus of the National Cancer Institute in Maryland, U.S.A.

Frederick, the second largest city in Maryland, is the hub of Frederick County, Maryland. Frederick was named one of the Top 100 Best Places to Live and is located within an hour of the NIH main campus in Bethesda, Washington, D.C. and Baltimore, MD. The city offers many outstanding schools, a balanced and thriving economy and a highly educated workforce. 

How To Apply: 

Applicants should send their CV and contact details for three references to Dr. Eugene Valkov: Informal inquiries are welcome.

Contact Name: 
Eugene Valkov
Contact E-mail: 
Contact Phone: 

HHS, NIH, and NCI are Equal Opportunity Employers