WNT/R-spondin signaling, embryonic development, cancer
We seek highly motivated Postdoctoral Fellows who are interested in developing independent research projects in the laboratory of Andres Lebensohn, Ph.D., a Principal Investigator in the Laboratory of Cellular and Molecular Biology (LCMB) at the Center for Cancer Research of the National Cancer Institute. We combine functional genomics, genetics, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development, and maintain them in adult life. A major focus of the lab is on WNT signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, and promotes adult tissue renewal and regeneration. We use powerful genetic screens in human cells to discover new regulatory mechanisms, and probe their molecular underpinning through biochemistry and cell biology to understand how they enable the pathway to generate distinct physiological outcomes. Based on this understanding we hope to devise more selective therapeutic strategies to target tumors driven by dysregulation of WNT signaling. Research project descriptions can be found at https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn. Fellows will have outstanding stipend support, funds for travel to scientific conferences, and full healthcare benefits.
Candidates must have completed a Ph.D. or M.D./Ph.D. and should be recent graduates or have less than 3 years of postdoctoral experience by the desired start date. Candidates with backgrounds in cell, stem cell, developmental or cancer biology are encouraged to apply. Experience in biochemistry, cell biological techniques, organoid tissue culture or mouse genetics is welcome but not required.
The laboratory is located at the NIH Bethesda campus within a vibrant biomedical research community, with access to state-of-the art research facilities and close links to the NIH Clinical Center, winner of the 2011 Lasker-Bloomberg Award for Public Service and one of the leading clinical research hospitals in the world. The open lab space, collegial atmosphere and joint weekly seminars shared by the seven groups of the LCMB (https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology) give fellows a strong support network and plenty of opportunities to present and discuss their research with close peers. A short metro ride to Washington D.C. and the surrounding areas provides fellows and their families easy access to numerous free museums (https://washington.org/free-things-to-do), excellent culinary choices and many outdoor activities.
Please send a cover letter describing your research accomplishments and future interests, including your specific interest in the lab, a CV with bibliography and contact information for three references to email@example.com. Please use the following email subject: Application for Postdoctoral Fellow position.
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