cancer therapy, molecular imaging, positron emission tomography (PET), targeted nuclide therapy, therapeutic radiation
The Escorcia Lab within the Molecular Imaging Program (MIP) at the National Cancer Institute (NCI) is seeking a highly motivated postdoctoral candidate with a background in cancer biology and/or radiation biology to lead projects to develop and assess new tumor-selective imaging and therapeutic agents. MIP provides a collaborative environment of experts in (radio)chemistry, biology and physics and offers a unique opportunity to translate successful imaging and therapeutic agents into clinical trials in the NCI.
The primary focus of the lab involves developing tumor-selective imaging agents (e.g. PET, SPECT) to inform cytotoxic therapies such as immuno-oncology agents, small molecule chemotherapy, external radiotherapy, or targeted radioimmunotherapy agents, which can be engineered in the lab. In addition, we aim to develop methods to enhance therapeutic efficacy of ionizing radiation, especially targeted nuclide therapies (TNTs), and utilize state of the art dose modeling and detection techniques to ensure therapeutic doses to tumors. Our group is uniquely poised to take advantage of recent approvals of TNTs in humans to expand the repertoire of preclinical agents and translate the most promising ones to the clinic.
Our approach is multidisciplinary and spans bioinformatics (e.g. analysis of RNASeq data) to help identify novel imaging and therapeutic targets, genetic engineering (e.g. CRISPR/Cas9) and pharmacologic manipulation to study radiosensitivity, as well as radio- and bioconjugate-chemistry and medical physics to generate/assess our imaging and therapeutic agents. Accordingly, the lab is part of a multidisciplinary team of chemists, physicists, biologists, and physician-scientists who all collaborate to advance the mission of the lab and MIP as a whole, providing an excellent environment for motivated postdoctoral candidates to learn and thrive as scientists.
Applicants must have Ph.D., or M.D., considerable laboratory experience as well as track record of publications and presentations to highlight written and verbal skills as well as organizational and analytic abilities.
The candidate must be willing to work with animals, radioactivity and have prior skills with in vitro and in vivo studies. Specifically, the fellow will be expected to perform and troubleshoot common in vitro assays (e.g. tissue culture, flow cytometry, Western blot, ELISA, cell survival assays, clonogenic assays), and in vivo studies (e.g. murine models; subcutaneous, intravenous injections; imaging studies; biodistribution, therapy and survival studies). There may also be opportunities to mentor undergraduate, and post-baccalaureate students as well.
To apply send a brief letter of interest, CV and the list of 3 references (with complete address) to Dr. Freddy Escorcia at firstname.lastname@example.org
• Please write: “Postdoctoral application” in the subject heading.
• Fellows with extramural fellowship applications are strongly encouraged to apply.
HHS, NIH, and NCI are Equal Opportunity Employers